WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Amyloid-beta (Aβ) is a 36–43 amino acid peptide derived from the proteolytic cleavage of amyloid precursor protein (APP) by beta-secretase (BACE1) and gamma-secretase. Its aggregation from soluble monomers into insoluble fibrillar plaques in the brain is the defining ne…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
A selective semipermeable border formed by brain endothelial cells connected by tight junctions, pericytes, and astrocytic end-feet. The BBB restricts passage of most molecules from blood to brain, protecting the CNS from toxins, pathogens, and inflammatory mediators. M…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Cirrhosis is end-stage liver fibrosis characterized by nodular regeneration, portal hypertension, and progressive hepatic failure. The gut-liver axis is central: portal venous blood delivers gut-derived LPS, bacterial DNA, and viable bacteria directly to the liver, and …
This page identifies the contradictions and clinical dilemmas that become visible only when the 236 source pages in this wiki are read together. Each paradox describes a situation where evidence-based dietary or supplementation advice -- advice that is correct for most …
Disruption of the normal composition and metabolic function of microbial communities, particularly the gut microbiome. In the metallomics context, dysbiosis is both a consequence of metal toxicity and an amplifier of further disease -- creating vicious cycles where meta…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
A family of Gram-negative, facultative anaerobic Gammaproteobacteria that includes many of the most important human pathogens: escherichia coli, klebsiella pneumoniae, salmonella typhimurium, shigella flexneri, yersinia pestis, proteus mirabilis, Morganella, and Serrati…
Escherichia is a genus of Gram-negative, facultatively anaerobic bacteria in the Enterobacteriaceae family. The primary species E. coli is simultaneously the most studied bacterium in biology and one of the most consistently enriched organisms in disease-associated micr…
An order of Gram-negative, obligate anaerobic bacteria within the phylum Fusobacteriota (formerly Fusobacteria). This order-level page covers the broader taxonomic group that includes the well-characterized genus fusobacterium and its key species fusobacterium nucleatum…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
Gut barrier dysfunction -- colloquially "leaky gut" -- is the pathological increase in intestinal permeability that permits translocation of bacteria, bacterial products (LPS, peptidoglycan), metals, and dietary antigens from the gut lumen into the systemic circulation.…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Hepatitis (liver inflammation) encompasses viral (HBV, HCV, HAV), autoimmune, alcoholic, and toxin-induced forms. In the WikiBiome framework, the gut-liver axis is central — portal blood delivers gut-derived microbial products (LPS, bacterial DNA) directly to the liver …
The intestinal epithelium is a single-cell-thick barrier separating the lumen -- home to trillions of microbes and ingested metals -- from the systemic circulation. When this barrier fails, the consequences cascade: microbial products translocate, metals gain unrestrict…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Microglia are the resident immune cells of the central nervous system, constituting 5-12% of all brain cells. They function as the brain's surveillance and defense system -- scanning for damage, clearing debris, pruning synapses during development, and mounting inflamma…
Mitochondrial dysfunction refers to the impairment of mitochondrial energy production, redox balance, and signaling functions. Mitochondria are the primary targets of heavy metal toxicity in human cells, and they are also the organelles most dependent on metal cofactors…
Necrotizing enterocolitis (NEC) is the most common and lethal gastrointestinal emergency in premature infants, affecting 5-12% of very low birth weight neonates (<1500 g) with mortality rates of 20-30%. Characterized by intestinal inflammation, necrosis, and perforation…
Chronic inflammatory activation within the central nervous system, driven by microglia, astrocytes, and infiltrating peripheral immune cells. Neuroinflammation is a convergent pathological mechanism across alzheimers disease, parkinsons disease, multiple sclerosis, and …
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) is a family of transcription factors that regulate inflammation, immune responses, cell survival, and proliferation. NF-kB is a convergence point where metal toxicity, pathogen signaling, and chronic…
The outer membrane (OM) is the defining structural feature of Gram-negative bacteria, providing a permeability barrier that profoundly influences metal acquisition, antibiotic resistance, immune activation, and virulence. For the microbiome-metal axis, the outer membran…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Sphingomonas is a genus of Gram-negative, aerobic, rod-shaped bacteria in the class Alphaproteobacteria, distinguished by the presence of sphingolipids in their outer membrane rather than the lipopolysaccharide (LPS) typical of most Gram-negative bacteria. Originally is…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.