WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
A protein (pre-haptoglobin-2) that reversibly modulates tight junction permeability in the intestinal epithelium. Identified by Alessio Fasano in 2000, zonulin is the only known physiological regulator of intestinal paracellular permeability and has become the most wide…
Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
Gut barrier dysfunction -- colloquially "leaky gut" -- is the pathological increase in intestinal permeability that permits translocation of bacteria, bacterial products (LPS, peptidoglycan), metals, and dietary antigens from the gut lumen into the systemic circulation.…
The intestinal epithelium is a single-cell-thick barrier separating the lumen -- home to trillions of microbes and ingested metals -- from the systemic circulation. When this barrier fails, the consequences cascade: microbial products translocate, metals gain unrestrict…