Evidence-based therapeutic approaches validated through the Triangle Test framework. 72 articles in this category.
Acarbose + High Fiber Diet Synergy For PCOS > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
B Cell Depletion Therapy For Multiple Sclerosis B cell depletion therapy (anti CD20 monoclonal antibodies, primarily ocrelizumab in MS) targets and depletes CD20+ B lymphocytes, which include mature B cell...
Berberine Berberine is an isoquinoline alkaloid from traditional Chinese medicine (Coptis chinensis, Berberis species) that acts as a prebiotic microbiome modulator ra...
Berberine + Methimazole For Graves' Disease Berberine is a plant alkaloid that activates AMPK (AMP activated protein kinase), a master metabolic regulator. It suppresses the NF kB signaling pathway, re...
Citrus Fruits For Endometriosis > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Dietary Fiber (Cross Condition) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Dietary Fiber For Colorectal Cancer Prevention Dietary fiber (cereals, fruits, vegetables, legumes) undergoes anaerobic fermentation by colonic bacteria, producing short chain fatty acids — primarily buty...
Dietary Fiber For Ovarian Cancer Risk Reduction High dietary fiber intake as a preventive strategy against ovarian cancer. This is the strongest epidemiological evidence for any dietary intervention in OC,...
Dietary Fiber Supplementation For CKD Dietary fiber supplementation (resistant starch, inulin, arabinoxlan oligosaccharides, or whole food fiber) to shift gut fermentation from proteolytic to sac...
E. Coli Nissle 1917 > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Exercise For Schizophrenia Moderate to vigorous exercise (~90 min/week) as adjunctive therapy alongside antipsychotics. The strongest evidence base of any non pharmacological intervent...
Faecalibacterium Prausnitzii Restoration > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Fecal Microbiota Transplantation (FMT) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Ferrichrome Producing Probiotics > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
High Fiber Diet (Cross Condition) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
High Fiber Prebiotics For Crohn'S Disease > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Hyperbaric Oxygen Therapy (HBOT) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation.
Indole 3 Carbinol (I3C) For Ovarian Cancer Indole 3 carbinol (I3C) and its metabolite 3,3' diindolylmethane (DIM) — derived from cruciferous vegetables and also produced by gut bacteria from tryptopha...
Iron Management > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Ketogenic Diet > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Ketogenic Diet For Multiple Sclerosis Ketogenic diet (KD) restricts carbohydrate availability to <50g/day, forcing reliance on fat metabolism and ketone body production. At the microbiome level, ...
Lactoferrin + L. Rhamnosus GG For NEC Prevention The combination of lactoferrin + L. rhamnosus GG (LGG) ranked SUCRA 95.7% for lowest NEC rate in a network meta analysis of 27 RCTs (n=9,501). This intervent...
Lactoferrin Supplementation (Cross Condition) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Low Carbohydrate Diet For GERD Low carbohydrate diets reduce esophageal acid exposure time from 5.1% to 2.5% (P=0.022) by decreasing gastric distension and transient lower esophageal sphin...
Low Carbohydrate Diet For PCOS > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Low Fat Diet For Endometriosis > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Low Nickel Diet > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Low Red Meat Diet For Endometriosis > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Magnesium Supplementation For Fibromyalgia > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Mediterranean Diet > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Mediterranean Diet For Fibromyalgia The Mediterranean diet demonstrated broad symptomatic improvement in fibromyalgia across multiple domains in an RCT (n=84), including pain, disability, fatig...
Mediterranean Diet For GERD The Mediterranean diet is associated with a 47% reduction in GERD odds (OR=0.53) at the highest adherence level. Multiple complementary mechanisms contribute...
Mediterranean Diet For Ovarian Cancer Survival Adherence to the Alternate Mediterranean Diet (AMED) pattern — high in fiber, polyphenols, omega 3 fatty acids, and plant based foods — as both a preventive ...
Mediterranean Diet For Type 1 Diabetes The Mediterranean diet improves glycemic control and cardiovascular risk in T1D youth while promoting butyrate producing taxa depleted in T1D, particularly F...
Multi Strain Synbiotic For Schizophrenia Multi strain synbiotic supplementation (probiotic + prebiotic) as adjunctive therapy alongside antipsychotics. This is the strongest validated microbiome tar...
N Acetylcysteine (NAC) For Autism Spectrum Disorder N Acetylcysteine (NAC) is a glutathione precursor and glutamatergic modulator that addresses two key features of ASD pathophysiology: oxidative stress and ex...
Omega 3 Fatty Acids (EPA/DHA) Omega 3 fatty acids — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — are anti inflammatory polyunsaturated fatty acids that counterbalance the ...
Plant Based Diet For CKD Plant based diets shift the gut microbiome from proteolytic to saccharolytic fermentation, reducing production of the uremic toxins indoxyl sulfate (IS) and ...
Prebiotics (Inulin + FOS) For PCOS > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Probiotic Combination For CKD Multi strain probiotic supplementation with L. acidophilus, B. longum, and B. bifidum has shown promise in slowing CKD progression through anti inflammatory ...
Probiotics (General) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Probiotics (Lactobacillus + Bifidobacterium) For PCOS > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Probiotics For Hashimoto'S Thyroiditis Probiotic supplementation targeting the dysbiosis thyroid axis aims to restore Lactobacillus and Bifidobacterium populations depleted in Hashimoto's thyroidi...
Probiotics For Postpartum Depression Probiotic supplementation targeting depleted Bifidobacterium and Lactobacillus in the postpartum period aims to restore gut brain axis signaling disrupted du...
Probiotics With PPI Therapy For GERD Co administration of multi strain probiotics (Bifidobacterium, Lactobacillus, Enterococcus, Bacillus cereus) alongside PPI therapy to mitigate PPI induced gu...
Quercetin (Cross Condition) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Saccharomyces Boulardii For Endometriosis > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Selenium Supplementation > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Simvastatin For Colorectal Cancer Simvastatin inhibits HMG CoA reductase, the rate limiting enzyme in cholesterol biosynthesis. Beyond its lipid lowering effects, simvastatin modulates gut mi...
Statins Statins (HMG CoA reductase inhibitors) are the most prescribed drug class worldwide for cholesterol lowering. In the WikiBiome framework, statins are notable...
Synbiotics For Pancreatic Ductal Adenocarcinoma Synbiotics combine probiotic strains (selected SCFA producers) with prebiotic fibers (inulin, FOS, or resistant starch) to restore the depleted commensal eco...
Vitamin D + Probiotic Combination For Schizophrenia Co supplementation of vitamin D3 (50,000 IU every 2 weeks) + 4 strain probiotic (L. acidophilus, B. bifidum, L. reuteri, L. fermentum; 8 x 10^9 CFU/day) for ...
Vitamin D + Probiotic Synergy (Cross Condition) > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Vitamin D Supplementation > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Zinc Supplementation > Research summary — not medical advice. This page synthesizes published research on a mechanism level intervention. It is not a clinical recommendation. Con...
Zinc Supplementation For Autism Spectrum Disorder Zinc supplementation addresses the functional zinc deficiency in ASD caused by toxic metal displacement at binding sites. Lead, mercury, and cadmium enter ce...