Metformin

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Overview

Metformin is discussed across 25 sources in the WikiBiome vault as a potential intervention. Triangle evidence linking this intervention to specific conditions needs to be populated from the source literature.

Triangle Evidence

No triangles populated yet. Sources discussing this intervention need to be reviewed and triangle edges (I→f, I→D, f→D) constructed per CLAUDE.md §4.

Cross-References

To be populated from source analysis.

References (8)

  1. Ilze Elbere, Ineta Kalnina, Ivars Silamikelis et al. (2018). Elbere et al. 2018 — Association of Metformin Administration with Gut Microbiome Dysbiosis in Healthy Volunteers. PLOS ONE. doi:10.1371/journal.pone.0204317
  2. Hao Wu, Eduardo Esteve, Valentina Tremaroli et al. (2017). Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nature Medicine
  3. Anna Griffith, Adam Perlman, Tara Karr et al. (2026). Griffith 2026 — Lifestyle Changes and Probiotic Supplementation for Improving Longstanding Type 2 Diabetes in a Male Undergoing Testosterone Replacement Therapy. Frontiers in Endocrinology. doi:10.3389/fendo.2025.1754430
  4. Elizabeth Varghese, Samson Mathews Samuel, Alena Liskova et al. (2021). Varghese 2021 — Diabetes and Coronavirus (SARS-CoV-2): Molecular Mechanism of Metformin Intervention and the Scientific Basis of Drug Repurposing. PLoS Pathogens. doi:10.1371/journal.ppat.1009634
  5. Tsushima Y, Nachawi N, Pantalone KM et al. (2024). Ketogenic diet improves fertility in patients with polycystic ovary syndrome: a brief report. Frontiers in Nutrition. doi:10.3389/fnut.2024.1450244
  6. Thomas Bryrup, Cecilie W. Thomsen, Timo Kern et al. (2019). Bryrup 2019 — Metformin-Induced Changes of the Gut Microbiota in Healthy Young Men: Results of a Non-Blinded, One-Armed Intervention Study. Diabetologia. doi:10.1007/s00125-019-4848-7
  7. Ying Xia, Ming Sun, Hai Huang et al. (2024). Drug Repurposing for Cancer Therapy. Signal Transduction and Targeted Therapy
  8. Wei Ma, Ji Chen, Yuhong Meng et al. (2018). Ma 2018 — Metformin Alters Gut Microbiota of Healthy Mice: Implication for Its Potential Role in Gut Microbiota Homeostasis. Frontiers in Microbiology. doi:10.3389/fmicb.2018.01336