Representative Clostridium butyricum vegetative rod forms, shown as eight bodies in seven single or paired groupings. This reconstruction is non-diagnostic, shows no visible spores, and is not a micrograph.
Scientific media record1 verified identifier
- Subject
- Clostridium butyricumtaxon · species
- Identifiers
- NCBITaxon:1492
- Review
- Editorial review completeIdentifiers authority-verified · Accessibility validated · · clostridium-butyricum|clostridium-butyricum-morphology-v1.webp
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- Trained-algorithmic mediaCreated with a trained generative algorithm and reviewed by WikiBiome for subject identity, scientific framing, identifiers, provenance, and accessibility.
- Scientific basis
- Clostridium butyricum — NCBI TaxonomyClostridium butyricum — LPSNClostridium butyricum type strain — BacDiveClostridium butyricum primary morphology reportClostridium butyricum morphology study
- License
- CC BY-SA 4.0Created
Clostridium butyricum is a spore-forming, obligate anaerobic, Gram-positive bacterium and one of the leading next-generation probiotic candidates. The MIYAIRI 588 strain (CBM 588) is approved as a pharmaceutical probiotic in Japan and has expanding clinical evidence across multiple conditions.
Evidence map4 cited passagesInspect provenance +
Lactate utilization: Converts lactate to butyrate, preventing harmful lactate accumulation in the gut.
T2D/testosterone: Case report of probiotic + lifestyle intervention improving T2D and testosterone.
MDD: Depleted in MDD with nickel-metal toxicity (NiMeTox) microbiome signature.
Male fertility: Discussed in gut-testis axis context.
Key Features#
Butyrate production: Produces butyrate via the acetyl-CoA pathway, making it functionally similar to Faecalibacterium prausnitzii but with the advantage of spore-forming stability (survives gastric transit, shelf-stable).
Lactate utilization: Converts lactate to butyrate, preventing harmful lactate accumulation in the gut.[1]Louis et al. 2022 — Microbial Lactate Utilisation and the Stability of the Gut MicrobiomeLouis P, et al. · 2022Open reference 1 ↓ T2D/testosterone: Case report of probiotic + lifestyle intervention improving T2D and testosterone.[2]Griffith 2026 — Lifestyle Changes and Probiotic Supplementation for Improving Longstanding Type 2 Diabetes in a Male Undergoing Testosterone Replacement TherapyAnna Griffith, Adam Perlman, Tara Karr et al. · 2026Open reference 2 ↓
MDD: Depleted in MDD with nickel-metal toxicity (NiMeTox) microbiome signature.[3]Maes 2026 — Functional Shotgun Metagenomic Insights into Gut Microbial Pathway and Enzyme Disruptions Linking Metabolism, Affect, Cognition, and Suicidal Ideation in Major Depressive DisorderMichael Maes, Abbas F. Almulla, Asara Vasupanrajit et al. · 2026Open reference 3 ↓ Male fertility: Discussed in gut-testis axis context.[4]Lv 2024 — Gut Microbiota Is Involved in Male Reproductive Function: A ReviewShuya Lv, Jingrong Huang, Yadan Luo et al. · 2024Open reference 4 ↓
Cross-References#
- butyrate—primary metabolic output
- Clostridium—genus context
- Faecalibacterium prausnitzii—functional parallel (both butyrate producers)
- Short-Chain Fatty Acids (SCFAs)—broader SCFA context
References 4
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Louis P, et al. (2022). Louis et al. 2022 — Microbial Lactate Utilisation and the Stability of the Gut Microbiome. Gut Microbiome.
- 2
Anna Griffith, Adam Perlman, Tara Karr et al. (2026). Griffith 2026 — Lifestyle Changes and Probiotic Supplementation for Improving Longstanding Type 2 Diabetes in a Male Undergoing Testosterone Replacement Therapy. Frontiers in Endocrinology.
- 3
Michael Maes, Abbas F. Almulla, Asara Vasupanrajit et al. (2026). Maes 2026 — Functional Shotgun Metagenomic Insights into Gut Microbial Pathway and Enzyme Disruptions Linking Metabolism, Affect, Cognition, and Suicidal Ideation in Major Depressive Disorder. Acta Neuropsychiatrica.
- 4
Shuya Lv, Jingrong Huang, Yadan Luo et al. (2024). Lv 2024 — Gut Microbiota Is Involved in Male Reproductive Function: A Review. Frontiers in Microbiology.
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