Representative Clostridium butyricum vegetative rod forms, shown as eight bodies in seven single or paired groupings. This reconstruction is non-diagnostic, shows no visible spores, and is not a micrograph.
Scientific media record1 verified identifier
- Subject
- Clostridium butyricumtaxon · species
- Identifiers
- NCBITaxon:1492
- Review
- Editorial review completeIdentifiers authority-verified · Accessibility validated · · clostridium-butyricum|clostridium-butyricum-morphology-v1.webp
- Digital source
- Trained-algorithmic mediaCreated with a trained generative algorithm and reviewed by WikiBiome for subject identity, scientific framing, identifiers, provenance, and accessibility.
- Scientific basis
- Clostridium butyricum — NCBI TaxonomyClostridium butyricum — LPSNClostridium butyricum type strain — BacDiveClostridium butyricum primary morphology reportClostridium butyricum morphology study
- License
- CC BY-SA 4.0Created
Clostridium butyricum is a spore-forming, obligate anaerobic, Gram-positive bacterium and one of the leading next-generation probiotic candidates. The MIYAIRI 588 strain (CBM 588) is approved as a pharmaceutical probiotic in Japan and has expanding clinical evidence across multiple conditions.
Evidence map4 cited passagesInspect provenance +
Lactate utilization: Converts lactate to butyrate, preventing harmful lactate accumulation in the gut.
T2D/testosterone: Case report of probiotic + lifestyle intervention improving T2D and testosterone.
MDD: Depleted in MDD with nickel-metal toxicity (NiMeTox) microbiome signature.
Male fertility: Discussed in gut-testis axis context.
Key Features#
Butyrate production: Produces butyrate via the acetyl-CoA pathway, making it functionally similar to Faecalibacterium prausnitzii but with the advantage of spore-forming stability (survives gastric transit, shelf-stable).
Lactate utilization: Converts lactate to butyrate, preventing harmful lactate accumulation in the gut.[1]Louis et al. 2022 — Microbial Lactate Utilisation and the Stability of the Gut MicrobiomeLouis P, et al. · 2022Open reference 1 ↓ T2D/testosterone: Case report of probiotic + lifestyle intervention improving T2D and testosterone.[2]Griffith 2026 — Lifestyle Changes and Probiotic Supplementation for Improving Longstanding Type 2 Diabetes in a Male Undergoing Testosterone Replacement TherapyAnna Griffith, Adam Perlman, Tara Karr et al. · 2026Open reference 2 ↓
MDD: Depleted in MDD with nickel-metal toxicity (NiMeTox) microbiome signature.[3]Maes 2026 — Functional Shotgun Metagenomic Insights into Gut Microbial Pathway and Enzyme Disruptions Linking Metabolism, Affect, Cognition, and Suicidal Ideation in Major Depressive DisorderMichael Maes, Abbas F. Almulla, Asara Vasupanrajit et al. · 2026Open reference 3 ↓ Male fertility: Discussed in gut-testis axis context.[4]Lv 2024 — Gut Microbiota Is Involved in Male Reproductive Function: A ReviewShuya Lv, Jingrong Huang, Yadan Luo et al. · 2024Open reference 4 ↓
Cross-References#
- butyrate—primary metabolic output
- Clostridium—genus context
- Faecalibacterium prausnitzii—functional parallel (both butyrate producers)
- Short-Chain Fatty Acids (SCFAs)—broader SCFA context
References 4
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Louis P, et al. (2022). Louis et al. 2022 — Microbial Lactate Utilisation and the Stability of the Gut Microbiome. Gut Microbiome.
- 2
Anna Griffith, Adam Perlman, Tara Karr et al. (2026). Griffith 2026 — Lifestyle Changes and Probiotic Supplementation for Improving Longstanding Type 2 Diabetes in a Male Undergoing Testosterone Replacement Therapy. Frontiers in Endocrinology.
- 3
Michael Maes, Abbas F. Almulla, Asara Vasupanrajit et al. (2026). Maes 2026 — Functional Shotgun Metagenomic Insights into Gut Microbial Pathway and Enzyme Disruptions Linking Metabolism, Affect, Cognition, and Suicidal Ideation in Major Depressive Disorder. Acta Neuropsychiatrica.
- 4
Shuya Lv, Jingrong Huang, Yadan Luo et al. (2024). Lv 2024 — Gut Microbiota Is Involved in Male Reproductive Function: A Review. Frontiers in Microbiology.
Article network
Mentioned here 4
Pages linking here 3
Connect the evidence
Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.
No discussion yet. Start with a precise question or a source-backed observation.
Published page changes
This record shows only material changes published on this page, including changes to its content, evidence, conclusions, or author context. Internal processes and discussion activity are excluded. Pending, declined, and withdrawn proposals remain private.
- published revision
Revised “Key Features”: now reads “- butyrate production: Produces butyrate via the acetyl-CoA”.
Revised “Key Features”: changed “- Butyrate production: Produces butyrate via the acetyl-CoA” to “- butyrate production: Produces butyrate via the acetyl-CoA”. · Karen Pendergrass · +2 −2
Inspect exact Git diff ↗ - published revision
Created “Clostridium butyricum”: Clostridium butyricum is a spore-forming, obligate anaerobic, Gram-positive bacterium and one of the leading next-generation probiotic candidates. The MIYAIRI 588 strain (CBM 588) is approved as a…
Created “Clostridium butyricum”: Clostridium butyricum is a spore-forming, obligate anaerobic, Gram-positive bacterium and one of the leading next-generation probiotic candidates. The MIYAIRI 588 strain (CBM 588) is approved as a… Published sections: Clostridium butyricum; Key Features; Cross-References. · WikiBiome Deploy Bot · +44 −0
Inspect exact Git diff ↗