Mechanisms5 sources
Allopregnanolone
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “MDD”
Ranked matches across titles, topics, categories, and article introductions.
11 records in this view
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Microorganisms4 sources
Clostridium butyricum
Clostridium butyricum is a spore-forming, obligate anaerobic, Gram-positive bacterium and one of the leading next-generation probiotic candidates. The MIYAIRI 588 strain (CBM 588) is approved as a pharmaceutical probiotic in Japan and has expanding clinical evidence acr…
Mechanisms5 sources
Cortisol
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
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Diseases10 sources
Depression
Depression is the most prevalent mental health disorder globally, affecting over 280 million people zhu 2025 microbiota gut brain axis depression review, and one of the most metal-sensitive conditions in this wiki. It sits at the convergence of nearly every pathway cata…
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Mechanisms8 sources
GABA (Gamma-Aminobutyric Acid)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
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Mechanisms10 sources
Kynurenine Pathway
The kynurenine pathway (KP) is the dominant route of tryptophan catabolism, accounting for approximately 95% of dietary tryptophan degradation. It produces a cascade of neuroactive, immunomodulatory, and potentially neurotoxic metabolites whose balance determines whethe…
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Diseases7 sources
Major Depressive Disorder
Major depressive disorder (MDD) is a psychiatric condition characterized by persistent depressed mood, anhedonia, and cognitive/somatic symptoms. In the WikiBiome framework, MDD is a paradigm case for the gut brain axis: gut dysbiosis drives systemic inflammation and ne…
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Diseases6 sources
Premenstrual Dysphoric Disorder
Premenstrual Dysphoric Disorder (PMDD) affects 3-8% of menstruating individuals Epperson et al. 2012, causing severe mood disturbances, irritability, anxiety, and physical symptoms during the luteal phase of the menstrual cycle. Distinguished from premenstrual syndrome …
Mechanisms4 sources
Premenstrual Syndrome
Premenstrual syndrome (PMS) affects an estimated 20-40% of women of reproductive age, characterized by cyclical physical and psychological symptoms in the luteal phase (post-ovulation, pre-menstruation). While PMS has traditionally been attributed solely to hormonal flu…
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Mechanisms5 sources
Serotonin-Estrogen Axis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Clinical cautions6 sources
STOP: Iron Supplementation for Depression-Associated Low Serum Metals
Harm potential: YELLOW — True iron deficiency anemia requires supplementation regardless of inflammatory state.