Defense

13 articles in this category.

• Biofilm — Structured microbial communities encased in a self produced extracellular polymeric substance (EP...
• Calprotectin (S100A8/A9) — A heterodimer of S100A8 and S100A9 calcium binding proteins that constitutes approximately 60% of...
• Glutathione (GSH) — The most abundant intracellular thiol and the master antioxidant of mammalian cells. Glutathione ...
• Hepcidin — The master regulator of systemic iron homeostasis. Hepcidin is a 25 amino acid peptide hormone pr...
• Inter Kingdom Metal Shielding — Microbial communities do not acquire and use metals in isolation. Within biofilms, polymicrobial ...
• Lactoferrin — An iron binding glycoprotein of the transferrin family that sequesters iron (and potentially othe...
• Lipocalin 2 — Lipocalin 2 (also known as NGAL — neutrophil gelatinase associated lipocalin, or siderocalin) is ...
• Metal Homeostasis — The biological processes by which organisms maintain proper intracellular and systemic concentrat...
• Metal Dependent Virulence — Transition metals serve as essential cofactors for pathogen virulence factors across virtually al...
• Pathogen Metal Acquisition Systems — Pathogens deploy dedicated cellular machinery to import, store, regulate, and when necessary expo...
• Siderophores — Siderophores are small, high affinity iron chelating molecules secreted by microorganisms to scav...
• Siderophores And Metallophores — Siderophores and metallophores are small molecule chelators secreted by pathogens to scavenge met...
• Transferrin — Transferrin is a glycoprotein (β₁ globulin, ~80 kDa) synthesized primarily by the liver that func...