Entity indexes10 sources
Serotonin
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “serotonin”
Ranked matches across titles, topics, categories, and article introductions.
17 records in this view
Mechanisms5 sources
Serotonin-Estrogen Axis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Diseases8 sources
Anxiety Disorders
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Microorganisms8 sources
Clostridia
A class of Gram-positive, obligate anaerobic bacteria within the phylum Firmicutes that represents the most functionally diverse and clinically significant taxonomic class in the human gut microbiome. Clostridia encompasses the dominant butyrate producers sustaining col…
Diseases18 sources
Colorectal Cancer
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Diseases10 sources
Depression
Depression is the most prevalent mental health disorder globally, affecting over 280 million people zhu 2025 microbiota gut brain axis depression review, and one of the most metal-sensitive conditions in this wiki. It sits at the convergence of nearly every pathway cata…
Reference0 sources
Glossary
Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
Mechanisms4 sources
Indoles
Microbial tryptophan metabolites produced by gut bacteria through the third branch of tryptophan metabolism -- the indole pathway. Unlike the host-dominated kynurenine pathway (~95% of Trp) and the serotonin pathway (~1-2%), the indole pathway is exclusively microbial a…
Diseases5 sources
Irritable Bowel Syndrome (IBS)
A functional gastrointestinal disorder affecting 10-15% of the global population, characterized by chronic abdominal pain, bloating, and altered bowel habits (diarrhea-predominant, constipation-predominant, or mixed) without identifiable structural pathology. From a met…
Diseases7 sources
Major Depressive Disorder
Major depressive disorder (MDD) is a psychiatric condition characterized by persistent depressed mood, anhedonia, and cognitive/somatic symptoms. In the WikiBiome framework, MDD is a paradigm case for the gut brain axis: gut dysbiosis drives systemic inflammation and ne…
Microorganisms5 sources
Paraprevotella
Paraprevotella is a genus of obligate anaerobic, Gram-negative bacteria in the family Prevotellaceae, related to prevotella. It is a gut commensal with emerging associations across neuropsychiatric and reproductive conditions. - Schizophrenia: Altered in gut-brain axis …
Diseases13 sources
Postpartum Depression
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Clinical cautions6 sources
STOP: Iron Supplementation for Depression-Associated Low Serum Metals
Harm potential: YELLOW — True iron deficiency anemia requires supplementation regardless of inflammatory state.
Mechanisms3 sources
Tryptamine
Tryptamine is a microbial decarboxylation product of tryptophan, produced by bacterial tryptophan decarboxylase (found in ruminococcus gnavus, Clostridium sporogenes, and others). It is a serotonin receptor agonist (particularly 5-HT4) that stimulates gut motility and f…
Mechanisms15 sources
Tryptophan
Tryptophan (Trp) is an essential amino acid that the human body cannot synthesize and must obtain from diet. It occupies a uniquely important position at the intersection of neuroscience, immunology, and microbial ecology because it is the sole precursor to serotonin, a…
Mechanisms9 sources
Tryptophan Metabolism
Tryptophan (Trp) is an essential amino acid metabolized via three competing pathways: the kynurenine pathway, the serotonin pathway, and the microbial indole pathway. The balance among these pathways is profoundly influenced by the gut microbiome, inflammation, and meta…
Microorganisms7 sources
Turicibacter
A Gram-positive, facultatively anaerobic genus within the class Erysipelotrichia (phylum Firmicutes) that has become one of the most frequently identified taxa in gut-brain and gut-immune Mendelian randomization studies. Turicibacter sanguinis, the type species, possess…