Diseases7 sources
Gastroesophageal Reflux Disease (GERD)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “cytokine”
Ranked matches across titles, topics, categories, and article introductions.
17 records in this view
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Reference0 sources
Glossary
Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
Mechanisms16 sources
Gut-Brain Axis
Bidirectional communication between the gut microbiota and the central nervous system, mediated by neural (vagus nerve, enteric nervous system), immune (cytokines, microglia), endocrine (HPA axis), and metabolic (SCFAs, neurotransmitter precursors, tryptophan metabolite…
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Host defenses5 sources
IFN-gamma (Interferon Gamma)
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Mechanisms5 sources
IL-10 (Interleukin-10)
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Mechanisms4 sources
IL-17 (Interleukin-17)
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Mechanisms5 sources
IL-1beta (Interleukin-1 Beta)
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Mechanisms9 sources
Immune Balance
The immune system is not a monolith but a dynamic equilibrium between pro-inflammatory effector responses (Th1, Th2, Th17) and anti-inflammatory regulatory responses (Treg, IL-10, TGF-beta). Metals and the microbiome are two of the most potent environmental modulators o…
Mechanisms13 sources
Interleukin-6 (IL-6)
Interleukin-6 is a pleiotropic cytokine that sits at the crossroads of innate immunity, adaptive immunity, and metabolism. It is one of the most frequently elevated inflammatory mediators across conditions in this wiki — appearing in disease signatures spanning IBD, aut…
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Analyses62 sources
Metal-Disease Matrix: A Cross-Source Synthesis
This page synthesizes findings across 1,426 source pages to map the relationships between metals and disease. Where individual source pages document a single study's findings, this page identifies the patterns that emerge when those findings are laid side by side. ADVER…
Host defenses12 sources
Metal-Driven Inflammation
Inflammation is a broad concept, but in the metallomics context it has a specific character: heavy metals and pathogens activate overlapping inflammatory pathways, creating convergent pathology where distinguishing the metal contribution from the microbial contribution …
Diseases5 sources
Multiple Sclerosis
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Mechanisms9 sources
Neuroinflammation
Chronic inflammatory activation within the central nervous system, driven by microglia, astrocytes, and infiltrating peripheral immune cells. Neuroinflammation is a convergent pathological mechanism across alzheimers disease, parkinsons disease, multiple sclerosis, and …
Mechanisms9 sources
NF-kB Signaling Pathway
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) is a family of transcription factors that regulate inflammation, immune responses, cell survival, and proliferation. NF-kB is a convergence point where metal toxicity, pathogen signaling, and chronic…
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Diseases18 sources
Schizophrenia
A severe neuropsychiatric disorder affecting approximately 1% of the global population, characterized by positive symptoms (hallucinations, delusions), negative symptoms (anhedonia, social withdrawal, flat affect), and cognitive deficits. Life expectancy is reduced by 1…
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Mechanisms6 sources
TGF-beta (Transforming Growth Factor Beta)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms13 sources
TNF-alpha (Tumor Necrosis Factor Alpha)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.