Diseases7 sources
Gastroesophageal Reflux Disease (GERD)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “PPIs”
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Mechanisms5 sources
Pharmacomicrobiomics
Pharmacomicrobiomics is the study of bidirectional interactions between drugs and the microbiome. The gut microbiome is not a passive bystander in pharmacology -- it actively metabolizes drugs, alters their bioavailability, and modulates therapeutic efficacy. Conversely…
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Clinical cautions4 sources
STOP: Long-Term PPI Monotherapy Without Microbiome Support in GERD
Harm potential: GREEN — PPIs remain appropriate first-line therapy; this STOP recommends co-administration of probiotics, not PPI avoidance.