STOP: Long Term PPI Monotherapy Without Microbiome Support In GERD

Overview

Harm potential: GREEN — PPIs remain appropriate first-line therapy; this STOP recommends co-administration of probiotics, not PPI avoidance.

References (4)

  1. Yin (2025). Yin 2025 — Probiotics Combined with PPI for GERD: Randomized Controlled Trial. Pharmacy Practice. doi:10.18549/PharmPract.2025.4.3225
  2. Yichao Shi, Jianfeng Li, Shuntian Cai et al. (2023). Shi 2023 — PPI-Induced Fungal Dysbiosis in Patients with Gastroesophageal Reflux Disease. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2023.1205348
  3. Park (2020). Park 2020 — NERD Treatment and Esophageal Microbiome. Scientific Reports. doi:10.1038/s41598-020-72082-8
  4. Deshpande NP, Riordan SM, Castano-Rodriguez N et al. (2018). Deshpande 2018 — Esophageal Microbiome Signatures and Host Genetics. Microbiome. doi:10.1186/s40168-018-0611-4

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