Interventions2 sources
Dietary Fiber Supplementation for CKD
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Search: “supplement”
Ranked matches across titles, topics, categories, and article introductions.
80 records in this view
Interventions2 sources
Glutathione Supplementation
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Interventions0 sources
L. rhamnosus GG Early-Life Supplementation for T1D Prevention
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Interventions0 sources
Lactoferrin Supplementation (Cross-Condition)
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Magnesium Supplementation for Fibromyalgia
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
N-Acetylcysteine (NAC) Supplementation (Cross-Condition)
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Selenium Supplementation
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Selenium Supplementation (200mcg/day) for Hashimoto's Thyroiditis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Clinical cautions6 sources
STOP: Calcium Supplementation with Cadmium Exposure
Research summary -- not medical advice. This page synthesizes published research on why a commonly recommended intervention requires careful consideration in the context of cadmium exposure. Consult a qualified healthcare provider before making changes to supplementatio…
Clinical cautions0 sources
STOP: Exclusive Formula Feeding Without Supplementation for NEC-Risk Infants
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions3 sources
STOP: Iodine Supplementation for Graves' Disease
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions4 sources
STOP: Iodine Supplementation for Hashimoto's Thyroiditis
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan.
Clinical cautions7 sources
STOP: Iron Supplementation (Oral) for IBD/Crohn's Disease
Research summary -- not medical advice. This page synthesizes published research on why a commonly prescribed intervention may be counterproductive in this specific clinical context. Consult a qualified healthcare provider before making any changes to treatment.
Clinical cautions4 sources
STOP: Iron Supplementation for Alzheimer's Disease
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan.
Clinical cautions5 sources
STOP: Iron Supplementation for Cardiovascular Disease-Associated Anemia
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Clinical cautions4 sources
STOP: Iron Supplementation for Colorectal Cancer
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Iron-deficiency anemia in colorectal can…
Clinical cautions2 sources
STOP: Iron Supplementation for Crohn's Disease
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions6 sources
STOP: Iron Supplementation for Depression-Associated Low Serum Metals
Harm potential: YELLOW — True iron deficiency anemia requires supplementation regardless of inflammatory state.
Clinical cautions1 sources
STOP: Iron Supplementation for Endometriosis
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions3 sources
STOP: Iron Supplementation for Graves' Disease
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions1 sources
STOP: Iron Supplementation for Long COVID
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions3 sources
STOP: Iron Supplementation for Multiple Sclerosis Anemia
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions3 sources
STOP: Iron Supplementation for Obesity-Associated Anemia
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Clinical cautions4 sources
STOP: Iron Supplementation for Parkinson's Disease Anemia
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions2 sources
STOP: Iron Supplementation for PCOS
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions5 sources
STOP: Iron Supplementation for Type 2 Diabetes-Associated Anemia
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Clinical cautions4 sources
STOP: Iron Supplementation in ASD Dysbiosis (Without Metal Dysregulation Assessment)
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions3 sources
STOP: Iron Supplementation in Schizophrenia with Neuroinflammation
Harm potential: YELLOW — True iron deficiency anemia requires supplementation.
Clinical cautions2 sources
STOP: Isolated Zinc Supplementation for PCOS
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions3 sources
STOP: SCFA Supplementation Without Clostridial Restoration in Multiple Sclerosis
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions1 sources
STOP: Zinc Supplementation for Endometriosis
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Clinical cautions3 sources
STOP: Zinc Supplementation in H. pylori Infection
Research summary -- not medical advice. This page synthesizes published research on why a commonly prescribed intervention may be counterproductive in this specific clinical context. Consult a qualified healthcare provider before making any changes to treatment.
Analyses0 sources
The chromium supplementation paradox — Type 2 Diabetes
While Cr(III) deficiency may contribute to glucose intolerance, supplementation trials have produced inconsistent results. The disconnect between mechanistic plausibility and clinical trial evidence suggests that Cr supplementation may only benefit the subset of patient…
Analyses0 sources
The Iron Supplementation Double-Edged Sword
Iron deficiency is common and clinically significant across multiple conditions: postpartum anemia increases PPD risk 1.89-fold (RR = 1.887), low ferritin (<1 ug) increases PPD risk 3.98-fold azami 2019 anemia ppd meta analysis, iron deficiency impairs thyroid peroxidas…
Analyses0 sources
The zinc supplementation question — Breast Cancer
Zinc deficiency is a consistent finding in breast cancer, and Zn plays key roles in immunity (T cell differentiation), p53 activation, and SOD cofactor function. Yet supplementation data are limited, and in the Sister Study, zinc showed a dose-related positive associati…
Interventions0 sources
Vitamin D Supplementation
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Zinc Supplementation
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Analyses0 sources
Zinc supplementation — Alzheimer's Disease
Could counter Zn depletion, but excess Zn promotes A-beta aggregation in plaques doroszkiewicz 2023 common trace metals alzheimers parkinsons.
Interventions0 sources
Zinc Supplementation for Autism Spectrum Disorder
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Interventions0 sources
Acarbose + High-Fiber Diet Synergy for PCOS
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Diseases20 sources
Alzheimer's Disease
The most common form of dementia, affecting an estimated 55 million people worldwide and projected to triple by 2050 zhang 2024 recent advances alzheimers mechanisms trials. Characterized by progressive memory loss, cognitive decline, amyloid-beta plaques, and neurofibr…
Interventions2 sources
Berberine
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Microorganisms5 sources
Bifidobacterium breve
Bifidobacterium breve is a Gram-positive, obligate anaerobic species within the phylum Actinobacteria, predominantly found in the infant gut and breast milk. It is among the earliest colonizers of the neonatal intestine and plays a key role in human milk oligosaccharide…
Interventions0 sources
Citrus Fruits for Endometriosis
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Diseases15 sources
Crohn's Disease
A chronic, relapsing-remitting inflammatory bowel disease (IBD) characterized by transmural inflammation of the gastrointestinal tract, most commonly affecting the terminal ileum and colon but capable of involving any segment from mouth to anus zhang 2017 intestinal mic…
Diseases10 sources
Depression
Depression is the most prevalent mental health disorder globally, affecting over 280 million people zhu 2025 microbiota gut brain axis depression review, and one of the most metal-sensitive conditions in this wiki. It sits at the convergence of nearly every pathway cata…
Interventions2 sources
Dietary Fiber (Cross-Condition)
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Host defenses4 sources
Dietary Iron and Gut Ecology
iron occupies a unique position among dietary metals: it is both an essential nutrient and a selective pressure that shapes the gut microbial ecosystem. The form, quantity, and bioavailability of dietary iron determines which microbes thrive and which are competitively …
Analyses31 sources
Dietary Metal Paradoxes: When Healthy Foods and Good Intentions Backfire
This page identifies the contradictions and clinical dilemmas that become visible only when the 236 source pages in this wiki are read together. Each paradox describes a situation where evidence-based dietary or supplementation advice -- advice that is correct for most …
Interventions1 sources
E. coli Nissle 1917
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Diseases11 sources
Endometriosis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Interventions0 sources
Faecalibacterium prausnitzii Restoration
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Mechanisms4 sources
Fecal Microbiota Transplant (FMT)
The transfer of processed stool from a healthy donor into a recipient's gastrointestinal tract to restore a disrupted microbial community. FMT is the most direct form of microbiome intervention -- replacing the entire community rather than supplementing individual strai…
Interventions0 sources
Fecal Microbiota Transplantation (FMT)
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Ferrichrome-Producing Probiotics
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Host defenses3 sources
Ferroportin
The only known cellular iron exporter in mammals. Encoded by the SLC40A1 gene, ferroportin (FPN) sits on the basolateral membrane of enterocytes, the surface of macrophages, and the membrane of hepatocytes, controlling the flow of iron from these cells into the bloodstr…
Diseases10 sources
Graves' Disease
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Diseases15 sources
Hashimoto's Thyroiditis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Host defenses6 sources
Hepcidin
The master regulator of systemic iron homeostasis. Hepcidin is a 25-amino-acid peptide hormone produced primarily by hepatocytes that controls iron absorption, recycling, and distribution by binding to and degrading ferroportin (SLC40A1/FPN) -- the only known cellular i…
Interventions1 sources
High-Fiber Diet (Cross-Condition)
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
High-Fiber Prebiotics for Crohn's Disease
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Iron Management
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Ketogenic Diet
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Lactoferrin + L. rhamnosus GG for NEC Prevention
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Interventions0 sources
Low-Carbohydrate Diet for PCOS
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Low-Fat Diet for Endometriosis
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions29 sources
Low-Nickel Diet
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Low-Red-Meat Diet for Endometriosis
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Metals10 sources
Magnesium
An essential macromineral required as a cofactor for over 300 enzymatic reactions in the body, including energy metabolism, protein synthesis, DNA/RNA stability, and neuromuscular function. Magnesium is not a heavy metal or trace element but is frequently measured along…
Interventions8 sources
Melatonin
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Diseases5 sources
Multiple Sclerosis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Interventions0 sources
N-Acetylcysteine (NAC) for Autism Spectrum Disorder
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Diseases18 sources
Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is the most common and lethal gastrointestinal emergency in premature infants, affecting 5-12% of very low birth weight neonates (<1500 g) with mortality rates of 20-30%. Characterized by intestinal inflammation, necrosis, and perforation…
Diseases11 sources
Obesity
A chronic metabolic condition affecting over 1 billion people globally, characterized by excess adipose tissue accumulation, systemic low-grade inflammation, and gut microbiome disruption pendergrass 2026 heavy metals obesity epidemic. From a metallomics perspective, ob…
Interventions8 sources
Omega-3 Fatty Acids (EPA/DHA)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms24 sources
Oxidative Stress
Oxidative stress is the imbalance between the production of reactive oxygen and nitrogen species (ROS/RNS) and the capacity of biological antioxidant defense systems to detoxify them. It is the single most commonly invoked mechanism across metal toxicology in this wiki,…
Diseases22 sources
Polycystic Ovary Syndrome
A metabolic-endocrine disorder affecting 6-20% of reproductive-age women worldwide, characterized by hyperandrogenism, oligo/anovulation, and polycystic ovary morphology (Rotterdam criteria) barrea 2019 mediterranean diet pcos. PCOS is the leading cause of anovulatory i…
Diseases13 sources
Postpartum Depression
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Interventions0 sources
Prebiotics (Inulin + FOS) for PCOS
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.
Interventions0 sources
Probiotics (General)
Research summary — not medical advice. This page synthesizes published research on a mechanism-level intervention. It is not a clinical recommendation. Consult a qualified healthcare provider before making any changes to diet, supplementation, or treatment.