STOP: SCFA Supplementation Without Clostridial Restoration In Multiple Sclerosis

Overview

> Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the strength of the mechanistic reasoning, not RCT-level clinical proof.

References (3)

  1. Anouck Becker, Mosab Abuazab, Andreas Schwiertz et al. (2021). Short-chain fatty acids and intestinal inflammation in multiple sclerosis: modulation of female susceptibility by microbial products?. Autoimmunity Highlights. doi:10.1186/s13317-021-00149-1
  2. Pavan Bhargava, Matthew D. Smith, Leah Mische et al. (2020). Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation. Journal of Clinical Investigation. doi:10.1172/JCI129401
  3. Alba Troci, Olga Zimmermann, Daniela Esser et al. (2022). B-cell-depletion reverses dysbiosis of the microbiome in multiple sclerosis patients. Scientific Reports. doi:10.1038/s41598-022-07336-8

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