Mechanisms13 sources
Metalloestrogens
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “metalloestrogens”
Ranked matches across titles, topics, categories, and article introductions.
16 records in this view
Mechanisms5 sources
Aromatase
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Diseases19 sources
Breast Cancer
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms5 sources
Endocrine Disruption
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms8 sources
Endocrine Disruptors
Exogenous chemicals that interfere with hormone synthesis, secretion, transport, binding, or elimination, mimicking or blocking endogenous hormones at physiologically relevant concentrations. In the metallomics-microbiome framework, endocrine disruptors occupy a critica…
Diseases11 sources
Endometriosis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms4 sources
Estrobolome
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Diseases13 sources
Female Infertility
Affects approximately 48 million women worldwide (WHO global infertility prevalence estimates). From a microbiome-metallomics perspective, female infertility sits at the intersection of the estrobolome (microbial estrogen metabolism), heavy metal reproductive toxicity (…
Reference0 sources
Glossary
Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
Analyses62 sources
Metal-Disease Matrix: A Cross-Source Synthesis
This page synthesizes findings across 1,426 source pages to map the relationships between metals and disease. Where individual source pages document a single study's findings, this page identifies the patterns that emerge when those findings are laid side by side. ADVER…
Mechanisms3 sources
Metalloestrogen
A metal ion that activates estrogen receptors and mimics the biological effects of estradiol. Metalloestrogens represent a distinct class of endocrine-disrupting compounds where the active agent is an inorganic metal rather than an organic xenoestrogen like BPA or phtha…
Diseases6 sources
Ovarian Cancer
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Diseases22 sources
Polycystic Ovary Syndrome
A metabolic-endocrine disorder affecting 6-20% of reproductive-age women worldwide, characterized by hyperandrogenism, oligo/anovulation, and polycystic ovary morphology (Rotterdam criteria) barrea 2019 mediterranean diet pcos. PCOS is the leading cause of anovulatory i…
Diseases4 sources
Premature Ovarian Insufficiency
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Analyses0 sources
The H2S/NF-kB Amplification Loop — Endometriosis
Lei et al. (2018) demonstrated that hydrogen sulfide promotes endometrial stromal cell proliferation via NF-kB activation. CBS and CSE (H2S-producing enzymes) are overexpressed in ectopic endometrium. NF-kB is also activated by nickel exposure in allergic contact mucosi…
Analyses0 sources
The zinc supplementation question — Breast Cancer
Zinc deficiency is a consistent finding in breast cancer, and Zn plays key roles in immunity (T cell differentiation), p53 activation, and SOD cofactor function. Yet supplementation data are limited, and in the Sister Study, zinc showed a dose-related positive associati…