[1]H2S promotes proliferation of endometrial stromal cells via activating the NF-kB pathway in endometriosisLei S, Cao Y, Sun J et al. · 2018Open reference 1 ↓ demonstrated that hydrogen sulfide promotes endometrial stromal cell proliferation via NF-kB activation. CBS and CSE (H2S-producing enzymes) are overexpressed in ectopic endometrium. NF-kB is also activated by nickel exposure in allergic contact mucositis. This creates a convergent pathway: dietary nickel activates NF-kB in the gut mucosa; H2S from endometriotic lesions activates NF-kB locally; both feed the same inflammatory cascade that promotes lesion growth. Inhibiting endogenous H2S production in vivo significantly reduced lesion number and weight in a mouse model.
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demonstrated that hydrogen sulfide promotes endometrial stromal cell proliferation via NF-kB activation. CBS and CSE (H2S-producing enzymes) are overexpressed in ectopic endometrium. NF-kB is also activated by nickel exposure in allergic contact mucositis. This creates a convergent pathway: dietary nickel activates NF-kB in the gut mucosa; H2S from endometri
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This paradox is indexed from the dietary metal analysis in Endometriosis.
References 1
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Lei S, Cao Y, Sun J et al. (2018). H2S promotes proliferation of endometrial stromal cells via activating the NF-kB pathway in endometriosis. American Journal of Translational Research.