Bifidobacterium Breve

Bifidobacterium breve is a Gram-positive, obligate anaerobic species within the phylum Actinobacteria, predominantly found in the infant gut and breast milk. It is among the earliest colonizers of the neonatal intestine and plays a key role in human milk oligosaccharide metabolism. As a widely studied probiotic species, B. breve has attracted attention for its immunomodulatory properties, particularly in neuropsychiatric contexts.

In a systematic review of probiotic interventions for schizophrenia, B. breve-containing formulations contributed to significant reductions in TNF-alpha levels, suggesting anti-inflammatory effects relevant to the gut-brain axis ([1], systematic review). The species has also been evaluated in autism spectrum disorder, where probiotic supplementation including B. breve showed potential for modulating gut-brain signaling and improving behavioral outcomes ([2], review). <!— NEEDS VERIFICATION — specific B. breve strain identification in these trials varies; strain-level effects may differ —>

Cross-References

References (7)

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  2. Pengya Feng, Shuai Zhao, Yangyang Zhang et al. (2023). Feng 2023 — Probiotics in Treatment of ASD: Gut-Brain Axis Perspectives. Frontiers in Microbiology. doi:10.3389/fmicb.2023.1123462
  3. Khatoon S, Kalam N, Rashid S et al. (2023). Effects of gut microbiota on neurodegenerative diseases. Frontiers in Aging Neuroscience. doi:10.2147/DDDT.S580330
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  5. Ye N, Song X, Yu J et al. (2025). Effects of Gut Microbiota Interventions on Patients with Schizophrenia: A Systematic Review and Meta-Analysis. Frontiers in Microbiology. doi:10.3389/fmicb.2025.1681559
  6. Yasufumi Saito, Takao Hinoi, Tomohiro Adachi et al. (2019). Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model. PLoS ONE. doi:10.1371/journal.pone.0216393
  7. Chen H, Wang L, Zhao L et al. (2021). Chen 2021 — Alterations of vaginal microbiota in women with infertility and Chlamydia trachomatis infection. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2021.698840

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