Interventions2 sources
Mediterranean Diet for Ovarian Cancer Survival
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “survival”
Ranked matches across titles, topics, categories, and article introductions.
14 records in this view
Microorganisms5 sources
Adherent-Invasive Escherichia coli (AIEC)
A pathotype of escherichia coli that adheres to and invades intestinal epithelial cells, survives and replicates within macrophages, and is strongly associated with ileal Crohn's disease. Unlike classical diarrheagenic E. coli pathotypes (EPEC, ETEC, EHEC), AIEC does no…
Microorganisms1 sources
Brucella
A genus of Gram-negative intracellular pathogens causing brucellosis, the most common bacterial zoonosis worldwide. Brucella species depend on nickel-activated urease for gastrointestinal survival during the initial phase of infection, and urease immunization has been s…
Metals56 sources
Copper
An essential trace element with a striking dual nature: required for survival as a cofactor for critical enzymes (SOD1, cytochrome c oxidase, ceruloplasmin), yet toxic in excess through Fenton-like redox cycling and mis metallation of iron-sulfur clusters. Copper is ele…
Microorganisms6 sources
Escherichia coli
A Gram-negative bacterium that spans the commensal-pathogen spectrum, with pathogenic variants (UPEC, STEC, EHEC) deploying nickel-dependent enzymes as virulence factors. E. coli is the model organism for nickel transport biology -- the NikABCDE system was first charact…
Microorganisms4 sources
Mycobacterium tuberculosis
The causative agent of tuberculosis (TB), the leading infectious disease killer worldwide (~1.3 million deaths annually). M. tuberculosis has an exceptionally complex metal biology: it deploys nickel-dependent hydrogenase and urease for intracellular survival, species-s…
Mechanisms9 sources
NF-kB Signaling Pathway
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) is a family of transcription factors that regulate inflammation, immune responses, cell survival, and proliferation. NF-kB is a convergence point where metal toxicity, pathogen signaling, and chronic…
Mechanisms8 sources
Nickel-Urease
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Microorganisms8 sources
Saccharomyces cerevisiae
Saccharomyces cerevisiae is a unicellular budding fungus (ascomycete) ubiquitous in fermentation, brewing, bread-making, and increasingly used as a pharmaceutical probiotic (Hatoum et al. 2012). The strain S. boulardii (also called S. cerevisiae var. boulardii) is the m…
Microorganisms10 sources
Salmonella
Salmonella is a genus of Gram-negative, facultatively anaerobic bacteria in the family Enterobacteriaceae. The two species — S. enterica (with 2,500 serovars including Typhimurium and Typhi) and S. bongori — cause a spectrum of disease from self-limiting gastroenteritis…
Microorganisms5 sources
Salmonella enterica serovar Typhimurium
A Gram-negative enteric pathogen that possesses four distinct [NiFe] hydrogenases -- the most of any well-characterized human pathogen. These hydrogenases are critical for intracellular survival within macrophages, and a triple hydrogenase mutant is 100% avirulent in mo…
Microorganisms3 sources
Shigella flexneri
A Gram-negative intracellular pathogen causing bacillary dysentery (shigellosis), responsible for approximately 165 million illness episodes and over 1 million deaths annually, predominantly in children under 5 in developing countries. S. flexneri relies on nickel-depen…
Microorganisms4 sources
Streptococcus mutans
The primary architect of dental caries -- the most prevalent chronic infectious disease worldwide. S. mutans is a Gram-positive, facultative anaerobe that colonizes tooth surfaces and produces the acid-rich, metal-managed biofilms known as dental plaque. What sets this …
Mechanisms6 sources
Urease
The most widespread nickel-dependent virulence factor across human pathogens. Urease is found in at least 40 prokaryotic and 9 eukaryotic pathogenic species, making it the single most important enzyme linking dietary/environmental nickel to infectious disease.