WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
The third nickel-dependent enzyme class in human pathogens, after urease and hydrogenase. Glyoxalase I detoxifies methylglyoxal, a reactive and toxic byproduct of glycolysis. While less well-known than urease or hydrogenase as a virulence factor, GloI is emerging as a s…
[NiFe] hydrogenases are the second major nickel-dependent virulence factor class in human pathogens. Less widespread than urease but critical for energy metabolism in gastric, enteric, and intracellular pathogens. The discovery that H. pylori hydrogenase powers CagA tra…
The most widespread nickel-dependent virulence factor across human pathogens. Urease is found in at least 40 prokaryotic and 9 eukaryotic pathogenic species, making it the single most important enzyme linking dietary/environmental nickel to infectious disease.