Overview
Burkholderiales is an order of Gram-negative Betaproteobacteria that includes environmentally versatile genera such as Ralstonia, Burkholderia, and Sutterella. Many members are notable for their metal resistance mechanisms, which enable survival in heavy metal-contaminated environments — a property that translates to competitive advantage in metal-burdened gut ecosystems.
In murine models of endometriosis, Burkholderiales abundance shifts as part of the broader gut microbiota alterations induced by the disease ([1]). Members of this order have also been identified in gut microbiome profiling of autism spectrum disorder cohorts, though their contribution to GI symptoms remains unclear ([2]).
Cross-References
- ralstonia — metal-resistant genus within Burkholderiales
- endometriosis — gut microbiota alterations
- autism spectrum disorder — ASD microbiome associations
- antimicrobial metals — metal resistance as ecological strategy