Cirrhosis is end-stage liver fibrosis characterized by nodular regeneration, portal hypertension, and progressive hepatic failure. The gut-liver axis is central: portal venous blood delivers gut-derived LPS, bacterial DNA, and viable bacteria directly to the liver, and cirrhosis-associated gut barrier failure amplifies this toxic load — creating a feed-forward cycle of endotoxemia → hepatic inflammation → further barrier disruption.
Key Connections
- Gut dysbiosis: Cirrhosis depletes Bacteroidetes and SCFA producers while enriching oral-origin taxa (Streptococcus, Veillonella) that translocate to the gut — a distinctive "oralization" of the gut microbiome jie 2017 gut microbiome acvd.
- Hepatic encephalopathy: Urease-producing gut bacteria (helicobacter pylori, klebsiella, proteus mirabilis) generate ammonia → portal circulation → brain toxicity.
- Metal hepatotoxicity: Chronic cadmium, arsenic, lead exposure drives hepatic fibrosis independently of viral or alcoholic causes jaishankar 2014 heavy metal toxicity mechanisms.
- Mediterranean diet: Protective dietary pattern associated with reduced cirrhosis progression latorre perez 2021 spanish gut microbiome mediterranean diet.
Cross-References
- hepatitis — primary cause of cirrhosis
- endotoxemia — portal LPS driving hepatic inflammation
- bacteremia — spontaneous bacterial peritonitis in cirrhosis
- cadmium — hepatotoxic metal