Cirrhosis

Key Connections#

Gut Dysbiosis: Cirrhosis depletes Bacteroidetes and SCFA producers while enriching oral-origin taxa (Streptococcus, Veillonella) that translocate to the gut—a distinctive "oralization" of the Gut Microbiome.^{[1]The gut microbiome in atherosclerotic cardiovascular diseaseZhuye Jie, Huihua Xia, Shi-Long Zhong et al. · 2017Open reference 1 ↓}

Hepatic encephalopathy: Urease-producing gut bacteria (Helicobacter pylori, Klebsiella, Proteus mirabilis) generate Ammonia → portal circulation → brain toxicity. Metal hepatotoxicity: Chronic Cadmium, Arsenic, Lead exposure drives hepatic fibrosis independently of viral or alcoholic causes.^{[2]Toxicity, Mechanism and Health Effects of Some Heavy MetalsMonisha Jaishankar, Tenzin Tseten, Naresh Anbalagan et al. · 2014Open reference 2 ↓}

Mediterranean diet: Protective dietary pattern associated with reduced cirrhosis progression.^{[3]Latorre-Pérez 2021 — The Spanish Gut Microbiome Reveals Links Between Microorganisms and Mediterranean DietAdriel Latorre-Pérez, Marta Hernández, Jose Ramón Iglesias et al. · 2021Open reference 3 ↓}