WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Necrotizing enterocolitis (NEC) is the most common and lethal gastrointestinal emergency in premature infants, affecting 5-12% of very low birth weight neonates (<1500 g) with mortality rates of 20-30%. Characterized by intestinal inflammation, necrosis, and perforation…
A chronic inflammatory bowel disease characterized by continuous mucosal inflammation of the colon, extending proximally from the rectum. Unlike crohns disease, UC is limited to the colon, affects only the mucosa/submucosa (not transmural), produces no skip lesions, and…
Cerebral palsy (CP) is the most common motor disability in childhood, affecting 2-3 per 1,000 live births allen 2021 multi organ dysfunction cerebral palsy. Characterized by non-progressive disturbances in movement and posture arising from injury to the developing brain…
Citrobacter is a genus of Gram-negative, facultatively anaerobic bacteria in the Enterobacteriaceae family, named for its ability to utilize citrate as a sole carbon source. Species include C. freundii, C. koseri, and C. rodentium (a mouse model for EHEC infection). In …
A Gram-positive, spore-forming, obligate anaerobic bacterium that is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in healthcare settings. In the metallomics framework, C. difficile sits at the intersection of metal-antibiotic co-selec…
Clostridium perfringens is a Gram-positive, strictly anaerobic, spore-forming bacterium infamous for causing gas gangrene, food poisoning, and necrotizing enterocolitis (NEC) in premature infants. It is one of the most widely distributed pathogenic bacteria in nature, f…
A chronic, relapsing-remitting inflammatory bowel disease (IBD) characterized by transmural inflammation of the gastrointestinal tract, most commonly affecting the terminal ileum and colon but capable of involving any segment from mouth to anus zhang 2017 intestinal mic…
This page unifies the infant formula contamination, pregnancy complications, autism spectrum disorder, necrotizing enterocolitis, and neurodevelopmental toxicity threads around a single organizing insight: metal toxicity is disproportionately severe during specific deve…
A Gram-negative obligate anaerobe that occupies a paradoxical niche in the gut microbiota: as a weak butyrate producer (short-chain fatty acid), it has anti-inflammatory potential; as a virulent invasive pathobiont in inflammatory bowel disease (particularly ulcerative …
Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
A Gram-negative, microaerophilic bacterium within the Epsilonproteobacteria (family Helicobacteraceae) that is the primary murine model of hepatobiliary and intestinal disease. Unlike its more famous relative helicobacter pylori, which colonizes the stomach, H. hepaticu…
An umbrella term for chronic relapsing-remitting inflammatory conditions of the gastrointestinal tract, principally crohns disease (CD; transmural, any GI segment) and ulcerative colitis (UC; mucosal, colon only). Approximately 6 million patients worldwide. IBD represen…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
See also: saccharomyces (genus page) Saccharomyces boulardii is a non-pathogenic yeast strain used as a probiotic across a wide range of gastrointestinal and inflammatory conditions. Taxonomically a strain of S. cerevisiae, it is phenotypically distinct — optimally acti…
Sphingomonas is a genus of Gram-negative, aerobic, rod-shaped bacteria in the class Alphaproteobacteria, distinguished by the presence of sphingolipids in their outer membrane rather than the lipopolysaccharide (LPS) typical of most Gram-negative bacteria. Originally is…
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
Research summary -- not medical advice. This page synthesizes published research on why a commonly prescribed intervention may be counterproductive in this specific clinical context. Consult a qualified healthcare provider before making any changes to treatment.
Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the str…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.