Barnesiella

Barnesiella is a genus of Gram-negative, obligate anaerobic bacteria within the phylum Bacteroidetes. It is a commensal member of the healthy human gut microbiota, recognized for its role in colonization resistance — the ability of the resident microbiome to prevent establishment of pathogenic or antibiotic-resistant organisms.

Barnesiella is consistently depleted in endometriosis-associated gut microbiome profiles. Studies examining the gut microbiota of women with endometriosis have found reduced Barnesiella abundance compared to healthy controls ([1], cross-sectional; [2], review). This depletion pattern is part of a broader loss of commensal Bacteroidetes observed in the condition ([3], narrative review). The functional consequence of Barnesiella loss may include reduced colonization resistance, allowing opportunistic taxa to expand in the dysbiotic gut environment characteristic of endometriosis.

Cross-References

References (3)

  1. Baris Ata, Sule Yildiz, Engin Turkgeldi et al. (2019). Ata 2019 — The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls. Scientific Reports. doi:10.1038/s41598-019-39700-6
  2. Carlos H Miyashira, Fernanda Reali Oliveira, Marina Paula Andres et al. (2022). Miyashira 2022 — The Microbiome and Endometriosis. Reproduction and Fertility. doi:10.1530/RAF-21-0113
  3. Hooi-Leng Ser, Siu-Jung Au Yong, Mohamad Nasir Shafiee et al. (2023). Ser 2023 — Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review. Microorganisms. doi:10.3390/microorganisms11020360

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