Lachnospira eligens

Reported Human-Microbiome Evidence#

In a prospective cohort of 307 adult men, Ma and colleagues associated greater fruit-fiber intake with increased source-labeled Eubacterium eligens and with pectinase PL9 expression to which that taxon contributed.^{[4]Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult menWenjie Ma, Long H. Nguyen, Mingyang Song et al. · 2021Open reference 4 ↓}

This supports a cohort-specific diet and carbohydrate-utilization association; it does not establish a universal clinical effect or a metal dependency.

Luo and colleagues reported that the source-labeled “Eubacterium eligens group” was associated with lower type 1 diabetes risk in their two-sample Mendelian-randomization analysis (IVW OR 0.64, 95% CI 0.50–0.81; FDR-adjusted P = 0.031).^{[5]Luo 2023 — Gut microbiota and type 1 diabetes: a two-sample bidirectional Mendelian randomization studyLuo M, Sun M, Wang T et al. · 2023Open reference 5 ↓}

A separate CKD Mendelian-randomization study reported a nominal risk-increasing association for the same group label (IVW OR 1.19, 95% CI 1.05–1.35; P = 0.006), while only the order Desulfovibrionales met that study's Bonferroni threshold.^{[6]Luo 2023 — Causal Effects of Gut Microbiota on the Risk of Chronic Kidney Disease: A Mendelian Randomization StudyMingli Luo, Jiahao Cai, Shulu Luo et al. · 2023Open reference 6 ↓}

These results concern genetically proxied group-level abundance in predominantly European-ancestry datasets; they neither demonstrate an intervention effect nor resolve which organisms within the legacy group drove the signals.

Other cited cohort and classifier records retain their authors' historical Eubacterium eligens or group wording for traceability.^{[7]Eggers 2023 — Prenatal lead exposure is negatively associated with gut microbiome in childhood (PROGRESS cohort)Shoshannah Eggers, Vishal Midya, Moira Bixby et al. · 2023Open reference 7 ↓[8]Prenatal Lead Exposure is Negatively Associated with the Gut Microbiome in ChildhoodEggers S, Midya V, Bixby M et al. · 2023Open reference 8 ↓[9]Latorre-Pérez 2021 — The Spanish Gut Microbiome Reveals Links Between Microorganisms and Mediterranean DietAdriel Latorre-Pérez, Marta Hernández, Jose Ramón Iglesias et al. · 2021Open reference 9 ↓[10]Peralta-Marzal 2024 — A Robust Microbiome Signature for Autism Spectrum Disorder Across Different Studies Using Machine LearningLucia N. Peralta-Marzal, David Rojas-Velazquez, Douwe Rigters et al. · 2024Open reference 10 ↓[11]Yao 2024 — Gut Microbiota and Menstrual Disorders: Two-Sample MR StudyYufan Yao, Haoran Hu, Longhao Chen et al. · 2024Open reference 11 ↓[12]He 2023 — Altered Gut Microbiota and Short-Chain Fatty Acids in Chinese Children with Constipated Autism Spectrum DisorderJianquan He, Xiuhua Gong, Bing Hu et al. · 2023Open reference 12 ↓}

Those associations do not by themselves establish causation, a disease-wide direction of effect, or species-level therapeutic benefit.