Representative Anaerotruncus morphology. A. colihominis is a nonmotile pleomorphic bacillus whose emended description reports occasional oval terminal spores; this reconstruction is not diagnostic.
Scientific media record1 verified identifier
- Subject
- Anaerotruncustaxon · genus
- Identifiers
- NCBITaxon:244127
- Review
- Editorial review completeIdentifiers authority-verified · Accessibility validated · · anaerotruncus|anaerotruncus-morphology-v1.webp
- Digital source
- Trained-algorithmic mediaCreated with a trained generative algorithm and reviewed by WikiBiome for subject identity, scientific framing, identifiers, provenance, and accessibility.
- Scientific basis
- Anaerotruncus — NCBI TaxonomyAnaerotruncus colihominis gen. nov., sp. nov.Emended Anaerotruncus colihominis description
- License
- CC BY-SA 4.0Created
Anaerotruncus is a Gram-positive obligate anaerobic genus within the Ruminococcaceae (Firmicutes). First isolated from human feces, it is a minor member of the healthy gut community that has attracted attention for its consistent enrichment in aging-related conditions and neurodegenerative disease.
Metal Dependencies#
Anaerotruncus species require iron for anaerobic metabolism. Their expansion in elderly populations may reflect the broader age-related shift in gut iron handling—increased systemic Metal-Driven Inflammation raises hepcidin, altering luminal iron pools in ways that reshape the competitive landscape among strict anaerobes.
Ecological Role#
In healthy adults, Anaerotruncus occupies a low-abundance niche. Its enrichment in elderly cohorts correlates with reduced microbial diversity and declining Butyrate-producing communities. Unlike beneficial Ruminococcaceae members such as Faecalibacterium prausnitzii, Anaerotruncus does not appear to produce significant butyrate, and its expansion may signal a functional shift within the family.
Conditions Associated#
Anaerotruncus is enriched in Alzheimer's Disease, age-related cognitive decline, and Clostridioides difficile infection. Its association with neurodegeneration has prompted investigation through the Gut-Brain Axis framework, though causality remains unestablished. It may serve as a biomarker for age-related gut ecosystem deterioration rather than a direct pathogenic driver.
Cross-References#
- Alzheimer's Disease—enrichment in neurodegeneration
- Iron—metabolic dependency
- Gut-Brain Axis—potential neuroinflammatory link
- aging—age-associated expansion pattern
References 8
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Lucia N. Peralta-Marzal, David Rojas-Velazquez, Douwe Rigters et al. (2024). Peralta-Marzal 2024 — A Robust Microbiome Signature for Autism Spectrum Disorder Across Different Studies Using Machine Learning. Scientific Reports.
- 2
Yufan Yao, Haoran Hu, Longhao Chen et al. (2024). Yao 2024 — Gut Microbiota and Menstrual Disorders: Two-Sample MR Study. Frontiers in Microbiology.
- 3
Shen Lin, Hongjin Wang, Jingjing Qiu et al. (2023). Lin 2023 — Gut Microbiota in Perimenopausal Panic Disorder. Frontiers in Psychiatry.
- 4
Yimin Xue, Shirong Lin, Mingguang Chen et al. (2024). Altered colonic microflora and its metabolic profile in mice with acute viral myocarditis induced by coxsackievirus B3. Virology Journal.
- 5
Zhang M, Fang J, Zheng C et al. (2024). Gut Microbiota and Autoimmune Neurologic Disorders: A Two-Sample Bidirectional Mendelian Randomization Study. Frontiers in Microbiology.
- 6
Wang K, Wang S, Chen Y et al. (2024). Causal relationship between gut microbiota and risk of gastroesophageal reflux disease: a genetic correlation and bidirectional Mendelian randomization study. Frontiers in Immunology.
- 7
Si Xian Ho, Jia-Hao Law, Chin-Wen Png et al. (2024). Alterations in colorectal cancer virome and its persistence after surgery. Scientific Reports.
- 8
Paola Bianchimano, Graham J. Britton, David S. Wallach et al. (2022). Mining the microbiota to identify gut commensals modulating neuroinflammation in a mouse model of multiple sclerosis. Microbiome.
Article network
Connect the evidence
Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.
No discussion yet. Start with a precise question or a source-backed observation.
Activity and accepted changes
Accepted researcher context, editorial status, public discussion, and upstream Git revisions are shown together. Pending, declined, and withdrawn proposals remain private.
- published revision
Backfill inflammation concept links
Karen Pendergrass · +1 −1
Inspect exact Git diff ↗ - published revision
massive wiki expansion: 149 stubs fixed, 100+ new pages, Rule 15 scan, keystone papers
WikiBiome Deploy Bot · +13 −7
Inspect exact Git diff ↗ - published revision
maintenance: 409 source fixes, 34 entity updates, 17 concept updates, 30 analysis outputs
WikiBiome Deploy Bot · +53 −0
Inspect exact Git diff ↗