Agathobacter rectalis

Reported Human-Microbiome Evidence#

The cited TEDDY record reports source-labeled Eubacterium rectale among short-chain-fatty-acid-producing taxa depleted in children who progressed to type 1 diabetes in a prospective cohort of 783 children.^{[5]Vatanen et al. 2018 — The Human Gut Microbiome in Early-Onset Type 1 Diabetes from the TEDDY StudyTommi Vatanen, Eric A. Franzosa, Randall Schwager et al. · 2018Open reference 5 ↓}

A cross-sectional CKD multi-omics study likewise reported source-labeled E. rectale depletion across its 88-participant severity cohort.^{[6]Wang 2023 — Perturbed Gut Microbiome and Metabolomes Across CKD SeverityWang, Li, Zhang et al. · 2023Open reference 6 ↓}

A 96-participant shotgun-metagenomics study of pancreatic ductal adenocarcinoma, autoimmune pancreatitis, and healthy controls reported E. rectale as a discriminating source-era species label and measured lower fecal butyrate in the cancer group.^{[7]The fecal microbiota of patients with pancreatic ductal adenocarcinoma and autoimmune pancreatitis characterized by metagenomic sequencingWenli Zhou, De Zhang, Zhengpeng Li et al. · 2021Open reference 7 ↓} These studies support cohort-specific associations, not causation or a clinical intervention.

Reviews cited by WikiBiome report historical E. rectale labels in cardiovascular and neurodegenerative literature.^{[8]The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic RegulationMd. Mominur Rahman, Fahadul Islam, Md. Harun-Or-Rashid et al. · 2022Open reference 8 ↓[9]The potential links between human gut microbiota and cardiovascular health and disease - is there a gut-cardiovascular axis?Catia Almeida, J. Guilherme Goncalves-Nobre, Diogo Alpuim Costa et al. · 2023Open reference 9 ↓[10]Effects of gut microbiota on neurodegenerative diseasesKhatoon S, Kalam N, Rashid S et al. · 2023Open reference 10 ↓} Their summaries do not establish a disease-wide effect.

Likewise, Mendelian-randomization records using the “Eubacterium rectale group” label concern a legacy genus-level feature rather than a verified A. rectalis species measurement.^{[11]Uncovering a Causal Connection between Gut Microbiota and Six Thyroid Diseases: A Two-Sample Mendelian Randomization StudyChen J, Wang Y, Yao H et al. · 2024Open reference 11 ↓[12]Wang K 2024 — Causal Gut Microbiota-GERD Associations via Bidirectional Mendelian RandomizationKui Wang, Suijian Wang, Yuhua Chen et al. · 2024Open reference 12 ↓}

The current cited record set does not substantiate a species-specific metal requirement, toxic-metal susceptibility mechanism, universal abundance range, or therapeutic conclusion. Those claims are therefore not carried into the reconciled page.