Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

22%: weighted overlap
29: shared signals

First condition

Second condition

Comparison

SchizophreniaandChronic Kidney Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

46: Schizophrenia references
34: Chronic Kidney Disease references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Glutathione (GSH)

Only in Schizophrenia

None indexed

Only in Chronic Kidney Disease

Alpha-Klotho

Taxa enriched

2 shared

Shared

Lactobacillus Enterobacteriaceae

Only in Schizophrenia

Prevotella Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Only in Chronic Kidney Disease

Escherichia coli Eggerthella lenta Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Pseudomonas aeruginosa

Taxa depleted

6 shared

Shared

Faecalibacterium prausnitzii Roseburia Coprococcus Blautia Bifidobacterium Lachnospiraceae

Only in Schizophrenia

Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Only in Chronic Kidney Disease

Lachnospira Prevotella Akkermansia muciniphila Eubacterium rectale Ruminococcus bromii Anaerostipes

Host response elevated

8 shared

Shared

CRPSCD14IL 6TNF-alpha (Tumor Necrosis Factor Alpha)NLRP3 InflammasomeMalondialdehydeHepcidin Lipocalin-2

Only in Schizophrenia

IL-1beta (Interleukin-1 Beta)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)Complement C4ACeruloplasmin Bound CopperCeruloplasmin ZonulinAlpha 1 Antitrypsin

Only in Chronic Kidney Disease

IL 18TLR2 TLR4NF KappaBFree Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)Uric AcidFerritin

Host response depleted

3 shared

Shared

Glutathione (GSH)Total Antioxidant CapacityVitamin D

Only in Schizophrenia

Anti Inflammatory CytokinesSCFAsZinc Finger Proteins

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsENOSGPX4

Ecological state

3 shared

Shared

SCFA DepletionGut Barrier DysfunctionGut Barrier Disruption

Only in Schizophrenia

Tryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisDialysis Irreversibility

Virulence and functional enzymes

2 shared

Shared

Beta-GlucuronidaseTryptophanase

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 Dioxygenase

Only in Chronic Kidney Disease

UreaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase