IL-8 (CXCL8) is the primary neutrophil chemokine—it recruits neutrophils to infection sites and activates their antimicrobial functions (oxidative burst, degranulation, NET formation).
In the WikiBiome context, IL-8 is notable for its vulnerability to gingipain degradation—P. gingivalis gingipains rapidly destroy IL-8, preventing neutrophil recruitment and enabling immune evasion.
Evidence map3 cited passagesInspect provenance +
Functional shielding: Mixed C. albicans + P. gingivalis biofilm caused near-complete IL-8 disappearance at 24h—gingipain RgpA rapidly degrades IL-8, and the fungal biofilm amplifies gingipain activity.
GERD: Esophageal dysbiosis drives IL-8 via TLR2/TLR4 → NF-kB, contributing to esophageal inflammation.
Perinatal depression: Part of inflammatory biomarker profile.
Key Interactions#
Functional shielding: Mixed C. albicans + P. gingivalis biofilm caused near-complete IL-8 disappearance at 24h—gingipain RgpA rapidly degrades IL-8, and the fungal biofilm amplifies gingipain activity.[1]Bartnicka et al. 2020 — Candida albicans Shields the Periodontal Killer Porphyromonas gingivalis from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival TissueDominika Bartnicka, Miriam Gonzalez-Gonzalez, Joanna Sykut et al. · 2020Open reference 1 ↓
GERD: Esophageal Dysbiosis drives IL-8 via TLR2/TLR4 → NF-kB, contributing to esophageal Metal-Driven Inflammation.[2]Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptomsChen S, Jiang D, Zhuang Q et al. · 2024Open reference 2 ↓[3]Understanding the Mechanisms Underlying Gastroesophageal Reflux Disease (GERD) Development: A Systematic ReviewIsmail MA, Althiyabi HA, Alotaibi NM et al. · 2025Open reference 3 ↓
Perinatal depression: Part of inflammatory biomarker profile.[4]Silva-Fernandes 2024 — Inflammatory Biomarkers and Perinatal Depression: A Systematic ReviewAnabela Silva-Fernandes, Ana Conde, Margarida Marques et al. · 2024Open reference 4 ↓
Cross-References#
- Interleukin-6 (IL-6)—co-elevated pro-inflammatory cytokine
- TNF-alpha (Tumor Necrosis Factor Alpha)—co-elevated; drives IL-8 transcription
- Porphyromonas gingivalis—gingipains degrade IL-8 for immune evasion
- Functional Shielding—biofilm-mediated IL-8 destruction
- NF-kB Signaling Pathway—transcriptional driver of IL-8
References 4
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
★Dominika Bartnicka, Miriam Gonzalez-Gonzalez, Joanna Sykut et al. (2020). Bartnicka et al. 2020 — Candida albicans Shields the Periodontal Killer Porphyromonas gingivalis from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival Tissue. International Journal of Molecular Sciences.
- 2
Chen S, Jiang D, Zhuang Q et al. (2024). Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptoms. Journal of Translational Medicine.
- 3
Ismail MA, Althiyabi HA, Alotaibi NM et al. (2025). Understanding the Mechanisms Underlying Gastroesophageal Reflux Disease (GERD) Development: A Systematic Review. TPM.
- 4
Anabela Silva-Fernandes, Ana Conde, Margarida Marques et al. (2024). Silva-Fernandes 2024 — Inflammatory Biomarkers and Perinatal Depression: A Systematic Review. PLOS ONE.
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