Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

12%: weighted overlap
16: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andChronic Kidney Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
34: Chronic Kidney Disease references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Only in Chronic Kidney Disease

Cadmium Lead Arsenic Mercury ChromiumIron In Tubular CellsThallium

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Enterobacteriaceae Escherichia coli Collinsella

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes Eggerthella

Only in Chronic Kidney Disease

Eggerthella lenta Desulfovibrionales FlavonifractorClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Taxa depleted

5 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Blautia Lachnospiraceae Akkermansia muciniphila

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Chronic Kidney Disease

Roseburia Lachnospira Coprococcus Prevotella Eubacterium rectale Ruminococcus bromii Anaerostipes

Host response elevated

3 shared

Shared

IL 6NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Chronic Kidney Disease

CRPIL 18TLR2 TLR4NLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidHepcidin Ferritin Lipocalin-2

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftSCFA DepletionGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases

Only in Chronic Kidney Disease

UreaseTryptophanaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase