Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

22%: weighted overlap
29: shared signals

First condition

Second condition

Comparison

Chronic Kidney DiseaseandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

34: Chronic Kidney Disease references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Zinc

Only in Chronic Kidney Disease

Alpha-Klotho

Only in Schizophrenia

None indexed

Taxa enriched

2 shared

Shared

Enterobacteriaceae Lactobacillus

Only in Chronic Kidney Disease

Escherichia coli Eggerthella lenta Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Pseudomonas aeruginosa

Only in Schizophrenia

Prevotella Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

6 shared

Shared

Faecalibacterium prausnitzii Roseburia Coprococcus Bifidobacterium Blautia Lachnospiraceae

Only in Chronic Kidney Disease

Lachnospira Prevotella Akkermansia muciniphila Eubacterium rectale Ruminococcus bromii Anaerostipes

Only in Schizophrenia

Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

8 shared

Shared

CRPIL 6TNF-alpha (Tumor Necrosis Factor Alpha)NLRP3 InflammasomeSCD14MalondialdehydeHepcidin Lipocalin-2

Only in Chronic Kidney Disease

IL 18TLR2 TLR4NF KappaBFree Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)Uric AcidFerritin

Only in Schizophrenia

IL-1beta (Interleukin-1 Beta)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)Complement C4ACeruloplasmin Bound CopperCeruloplasmin ZonulinAlpha 1 Antitrypsin

Host response depleted

3 shared

Shared

Vitamin DTotal Antioxidant CapacityGlutathione (GSH)

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsENOSGPX4

Only in Schizophrenia

Anti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

3 shared

Shared

SCFA DepletionGut Barrier DysfunctionGut Barrier Disruption

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisDialysis Irreversibility

Only in Schizophrenia

Tryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

2 shared

Shared

TryptophanaseBeta-Glucuronidase

Only in Chronic Kidney Disease

UreaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 Dioxygenase