Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

12%: weighted overlap
16: shared signals

First condition

Second condition

Comparison

Chronic Kidney DiseaseandGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

34: Chronic Kidney Disease references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Chronic Kidney Disease

Cadmium Lead Arsenic Mercury ChromiumIron In Tubular CellsThallium

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Metals depleted or redistributed

2 shared

Taxa enriched

3 shared

Shared

Escherichia coli Enterobacteriaceae Collinsella

Only in Chronic Kidney Disease

Eggerthella lenta Desulfovibrionales FlavonifractorClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes Eggerthella

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Akkermansia muciniphila Bifidobacterium Blautia Lachnospiraceae

Only in Chronic Kidney Disease

Roseburia Lachnospira Coprococcus Prevotella Eubacterium rectale Ruminococcus bromii Anaerostipes

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Host response elevated

3 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)NF KappaB

Only in Chronic Kidney Disease

CRPIL 18TLR2 TLR4NLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidHepcidin Ferritin Lipocalin-2

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Ecological state

0 shared

Shared

None indexed

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftSCFA DepletionGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Chronic Kidney Disease

UreaseTryptophanaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases