Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

SchizophreniaandColorectal Cancer

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

46: Schizophrenia references
36: Colorectal Cancer references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Copper Iron Lead Cadmium Arsenic

Only in Schizophrenia

None indexed

Only in Colorectal Cancer

Zinc Nickel Chromium

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Bifidobacterium Lachnospiraceae

Only in Schizophrenia

Coprococcus Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Lactobacillus Ruminococcus

Host response elevated

5 shared

Shared

IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)Hepcidin Lipocalin-2

Only in Schizophrenia

CRPSCD14IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin ZonulinAlpha 1 Antitrypsin

Only in Colorectal Cancer

Lipopolysaccharide Calprotectin (S100A8/A9)

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Ecological state

1 shared

Shared

SCFA Depletion

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Only in Colorectal Cancer

Hypoxia BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksSiderophores Urease Glyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase