Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
20: shared signals

First condition

Second condition

Comparison

Colorectal CancerandChronic Kidney Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

36: Colorectal Cancer references
34: Chronic Kidney Disease references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Cadmium Lead Nickel Arsenic Chromium

Only in Colorectal Cancer

Iron Zinc Copper

Only in Chronic Kidney Disease

MercuryIron In Tubular CellsThallium

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Colorectal Cancer

Fusobacterium nucleatum Fusobacterium varium Bacteroides fragilis Parvimonas micra Peptostreptococcus stomatis Clostridium symbiosum Porphyromonas gingivalis Akkermansia muciniphila Candida albicans Peptostreptococcus anaerobius Enterococcus faecalis Streptococcus gallolyticus Saccharomyces cerevisiae

Only in Chronic Kidney Disease

Eggerthella lenta Enterobacteriaceae Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Taxa depleted

4 shared

Shared

Lachnospiraceae Faecalibacterium prausnitzii Roseburia Bifidobacterium

Only in Colorectal Cancer

Prevotella copri Ruminococcus albus Dialister Lactobacillus Ruminococcus

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Akkermansia muciniphila Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Host response elevated

4 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)Hepcidin Lipocalin-2

Only in Colorectal Cancer

IL-1beta (Interleukin-1 Beta)Lipopolysaccharide Calprotectin (S100A8/A9)

Only in Chronic Kidney Disease

CRPIL 18TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidFerritin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Colorectal Cancer

IL-10 (Interleukin-10)IgATreg CellsSelenium Dependent Glutathione Peroxidase

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

1 shared

Shared

SCFA Depletion

Only in Colorectal Cancer

Hypoxia BiofilmSecondary Bile Acid AccumulationFermentative Acidic MicroenvironmentEpithelial Barrier DisruptionColonic Serotonin DepletionAnaerobic DominanceSecondary Bile Acid ExcessWarburg EffectCross Kingdom DysbiosisVirome Network Disruption

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Virulence and functional enzymes

3 shared

Shared

Siderophores Urease Beta-Glucuronidase

Only in Colorectal Cancer

FadAFap2LPS TLR4BFT ToxinColibactin PksGlyoxalase IBFT Zinc MetalloproteaseColibactin GenotoxinFadA AdhesinFap2 LectinNAD(P)H Oxidase

Only in Chronic Kidney Disease

TryptophanaseTyrosine DecarboxylaseTMA LyaseAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase