Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Chronic Kidney DiseaseandCardiovascular Disease

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

34: Chronic Kidney Disease references
24: Cardiovascular Disease references
1: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Chronic Kidney Disease

Alpha-Klotho Zinc

Only in Cardiovascular Disease

Selenium Iron Manganese

Taxa enriched

3 shared

Shared

Escherichia coli Eggerthella lenta Enterobacteriaceae

Only in Chronic Kidney Disease

Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Only in Cardiovascular Disease

Streptococcus Bacteroides fragilis Porphyromonas gingivalis Ruminococcus gnavus Candida albicans Malassezia

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Akkermansia muciniphila Bifidobacterium Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Only in Cardiovascular Disease

Allisonella Clostridium Clostridiales Mycobiome

Host response elevated

2 shared

Shared

Hepcidin Lipocalin-2

Only in Chronic Kidney Disease

CRPIL 6IL 18TNF-alpha (Tumor Necrosis Factor Alpha)TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidFerritin

Only in Cardiovascular Disease

Calprotectin (S100A8/A9)TransferrinLipopolysaccharide LPSCeruloplasmin

Host response depleted

4 shared

Shared

ButyratePropionateAcetate Glutathione (GSH)

Only in Chronic Kidney Disease

Alpha-KlothoIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Only in Cardiovascular Disease

SeleniumSelenoproteinsGlutathione Peroxidase

Ecological state

0 shared

Shared

None indexed

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftSCFA DepletionGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Only in Cardiovascular Disease

HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilm EndotoxemiaOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Virulence and functional enzymes

3 shared

Shared

TryptophanaseSiderophores Beta-Glucuronidase

Only in Chronic Kidney Disease

UreaseTyrosine DecarboxylaseTMA LyaseAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinIndole ProductionHSP60TMA Lyase CutC CutDLPS Biosynthesis Enzymes