Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Cardiovascular DiseaseandChronic Kidney Disease

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

24: Cardiovascular Disease references
34: Chronic Kidney Disease references
1: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Cardiovascular Disease

Selenium Iron Manganese

Only in Chronic Kidney Disease

Alpha-Klotho Zinc

Taxa enriched

3 shared

Shared

Enterobacteriaceae Escherichia coli Eggerthella lenta

Only in Cardiovascular Disease

Streptococcus Bacteroides fragilis Porphyromonas gingivalis Ruminococcus gnavus Candida albicans Malassezia

Only in Chronic Kidney Disease

Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Taxa depleted

3 shared

Shared

Roseburia Faecalibacterium prausnitzii Lachnospiraceae

Only in Cardiovascular Disease

Allisonella Clostridium Clostridiales Mycobiome

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Akkermansia muciniphila Bifidobacterium Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Host response elevated

2 shared

Shared

Hepcidin Lipocalin-2

Only in Cardiovascular Disease

Calprotectin (S100A8/A9)TransferrinLipopolysaccharide LPSCeruloplasmin

Only in Chronic Kidney Disease

CRPIL 6IL 18TNF-alpha (Tumor Necrosis Factor Alpha)TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidFerritin

Host response depleted

4 shared

Shared

Glutathione (GSH)ButyratePropionateAcetate

Only in Cardiovascular Disease

SeleniumSelenoproteinsGlutathione Peroxidase

Only in Chronic Kidney Disease

Alpha-KlothoIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

0 shared

Shared

None indexed

Only in Cardiovascular Disease

HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilm EndotoxemiaOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftSCFA DepletionGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Virulence and functional enzymes

3 shared

Shared

Beta-GlucuronidaseTryptophanaseSiderophores

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinIndole ProductionHSP60TMA Lyase CutC CutDLPS Biosynthesis Enzymes

Only in Chronic Kidney Disease

UreaseTyrosine DecarboxylaseTMA LyaseAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase