Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Alzheimer's DiseaseandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Alzheimer's Disease references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Cadmium Arsenic Iron Copper

Only in Alzheimer's Disease

Manganese Mercury AluminumZinc In PlaquesNickel

Only in Schizophrenia

None indexed

Metals depleted or redistributed

2 shared

Shared

Zinc Glutathione (GSH)

Only in Alzheimer's Disease

Copper SeleniumCopper BrainZinc Serum

Only in Schizophrenia

None indexed

Taxa enriched

2 shared

Taxa depleted

4 shared

Shared

Lachnospiraceae Roseburia Blautia Faecalibacterium prausnitzii

Only in Alzheimer's Disease

Saccharomyces Ruminococcus Eubacterium rectale Bacteroides

Only in Schizophrenia

Coprococcus Saccharomyces cerevisiae Bifidobacterium Desulfovibrio Veillonellaceae

Host response elevated

2 shared

Shared

Hepcidin Lipocalin-2

Only in Alzheimer's Disease

Calprotectin (S100A8/A9)Proinflammatory CytokinesTransferrin Receptor AlteredFerritin AlteredTREM2

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin ZonulinAlpha 1 Antitrypsin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Alzheimer's Disease

ButyratePropionateIndole DerivativesTryptophan MetabolitesSelenoproteinsCeruloplasmin Function

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

2 shared

Shared

Microglial ActivationSCFA Depletion

Only in Alzheimer's Disease

Hypoxia DysbiosisBarrier DysfunctionNeuroinflammationAmyloid SeedingLPS TranslocationBlood Brain Barrier DisruptionAmyloid Cross SeedingLPS EndotoxemiaTMAO ElevationFerroptosisEpigenetic Latency

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Alzheimer's Disease

Curli FibersLipopolysaccharideBacterial AmyloidsSiderophores UreaseMetalloproteasesNickel-UreaseCurli AmyloidLPS

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase