Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

17%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

SchizophreniaandCardiovascular Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

46: Schizophrenia references
24: Cardiovascular Disease references
0: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Schizophrenia

Zinc

Only in Cardiovascular Disease

Selenium Iron Manganese

Taxa enriched

3 shared

Shared

Enterobacteriaceae Streptococcus Candida albicans

Only in Schizophrenia

Lactobacillus Prevotella VeillonellaSuccinivibrioTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Only in Cardiovascular Disease

Escherichia coli Bacteroides fragilis Porphyromonas gingivalis Eggerthella lenta Ruminococcus gnavus Malassezia

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae

Only in Schizophrenia

Coprococcus Blautia Saccharomyces cerevisiae Bifidobacterium Desulfovibrio Veillonellaceae

Only in Cardiovascular Disease

Allisonella Clostridium Clostridiales Mycobiome

Host response elevated

3 shared

Shared

Ceruloplasmin Hepcidin Lipocalin-2

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperZonulinAlpha 1 Antitrypsin

Only in Cardiovascular Disease

Calprotectin (S100A8/A9)TransferrinLipopolysaccharide LPS

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Only in Cardiovascular Disease

ButyratePropionateAcetate SeleniumSelenoproteinsGlutathione Peroxidase

Ecological state

0 shared

Shared

None indexed

Only in Schizophrenia

SCFA DepletionGut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Only in Cardiovascular Disease

HypoxiaTMAO Production DominanceLPS EndotoxemiaIndoxyl Sulfate AccumulationReduced Butyrate EcosystemFunctional ShieldingOral To Gut TranslocationBiofilm EndotoxemiaOral Gut TranslocationTMAO AccumulationFungal Bacterial Co Dysbiosis

Virulence and functional enzymes

2 shared

Shared

Beta-GlucuronidaseTryptophanase

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 Dioxygenase

Only in Cardiovascular Disease

TMA Lyase CutC/DLipopolysaccharide LPS BiosynthesisSiderophores Enterobactin YersiniabactinIndole ProductionHSP60TMA Lyase CutC CutDLPS Biosynthesis EnzymesSiderophores