Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

Postpartum DepressionandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

56: Postpartum Depression references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Copper Cadmium Lead

Only in Postpartum Depression

None indexed

Only in Schizophrenia

Iron Arsenic

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Enterobacteriaceae

Only in Postpartum Depression

AlphaproteobacteriaBilophila Desulfovibrio Escherichia coli Dialister Enterococcus

Only in Schizophrenia

Lactobacillus Prevotella Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

4 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae Coprococcus

Only in Postpartum Depression

Phascolarctobacterium Veillonella Eubacterium Clostridium Butyricicoccus Holdemanella

Only in Schizophrenia

Roseburia Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

5 shared

Shared

HepcidinIL 6CRPTNF-alpha (Tumor Necrosis Factor Alpha)Ceruloplasmin

Only in Postpartum Depression

IDOCopper

Only in Schizophrenia

SCD14IL-1beta (Interleukin-1 Beta)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperLipocalin-2 ZonulinAlpha 1 Antitrypsin

Host response depleted

0 shared

Shared

None indexed

Only in Postpartum Depression

Zinc Tryptophan GABA (Gamma-Aminobutyric Acid)SCFAFerritin Selenium

Only in Schizophrenia

Glutathione (GSH)Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

2 shared

Shared

SCFA DepletionTryptophan Kynurenine Shunting

Only in Postpartum Depression

Postpartum Hormonal CrashEstrogen Progesterone WithdrawalIDO Kynurenine ActivationTryptophan DiversionHPA Axis DysregulationGut Brain Axis DisruptionBile Acid DysmetabolismPrenatal Microbiome SeedingIntergenerational Dysbiosis TransmissionBarrier DysfunctionHormonal DysregulationIntergenerational Microbiome Transmission

Only in Schizophrenia

Gut Barrier DysfunctionTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Postpartum Depression

LPS EndotoxinIDO Indoleamine 2 3 DioxygenaseBile Salt Hydrolase (BSH)Sulfite ReductaseSiderophores EnterobactinSiderophoresLPS Biosynthesis Enzymes

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase