Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

ObesityandChronic Kidney Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
34: Chronic Kidney Disease references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Magnesium Barium Vanadium Titanium

Only in Chronic Kidney Disease

Alpha-Klotho Zinc

Taxa enriched

2 shared

Shared

Escherichia coli Enterobacteriaceae

Only in Obesity

Streptococcus Fusobacterium Bacteroides fragilis

Only in Chronic Kidney Disease

Eggerthella lenta Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae Akkermansia muciniphila Bifidobacterium

Only in Obesity

Oscillospiraceae

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Host response elevated

3 shared

Shared

Hepcidin Lipocalin-2 Ferritin

Only in Obesity

Calprotectin (S100A8/A9)Transferrin Lactoferrin

Only in Chronic Kidney Disease

CRPIL 6IL 18TNF-alpha (Tumor Necrosis Factor Alpha)TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric Acid

Host response depleted

2 shared

Shared

Glutathione (GSH)Butyrate

Only in Obesity

Short-Chain Fatty Acids (SCFAs)

Only in Chronic Kidney Disease

Alpha-KlothoPropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

0 shared

Shared

None indexed

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftSCFA DepletionGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Virulence and functional enzymes

3 shared

Shared

TMA LyaseSiderophores Beta-Glucuronidase

Only in Obesity

Nickel-UreaseNickel HydrogenaseZinc MetalloproteasesLPS Biosynthesis

Only in Chronic Kidney Disease

UreaseTryptophanaseTyrosine DecarboxylaseAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase