Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
15: shared signals

First condition

Second condition

Comparison

ObesityandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Magnesium Barium Vanadium Titanium

Only in Schizophrenia

Zinc

Taxa enriched

2 shared

Shared

Streptococcus Enterobacteriaceae

Only in Obesity

Escherichia coli Fusobacterium Bacteroides fragilis

Only in Schizophrenia

Lactobacillus Prevotella VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae Bifidobacterium

Only in Obesity

Akkermansia muciniphila Oscillospiraceae

Only in Schizophrenia

Coprococcus Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

2 shared

Shared

Hepcidin Lipocalin-2

Only in Obesity

Calprotectin (S100A8/A9)Transferrin Lactoferrin Ferritin

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin ZonulinAlpha 1 Antitrypsin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Obesity

Butyrate Short-Chain Fatty Acids (SCFAs)

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

0 shared

Shared

None indexed

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Schizophrenia

SCFA DepletionGut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisBeta-Glucuronidase

Only in Obesity

TMA LyaseSiderophores Nickel-UreaseNickel HydrogenaseZinc Metalloproteases

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase