Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

SchizophreniaandPolycystic Ovary Syndrome

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

46: Schizophrenia references
25: Polycystic Ovary Syndrome references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Copper Iron Lead Cadmium Arsenic

Only in Schizophrenia

None indexed

Only in Polycystic Ovary Syndrome

Mercury Antimony Nickel Zinc Manganese

Metals depleted or redistributed

1 shared

Taxa enriched

1 shared

Shared

Prevotella

Only in Schizophrenia

Lactobacillus Enterobacteriaceae Streptococcus VeillonellaSuccinivibrioCandida albicansTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Only in Polycystic Ovary Syndrome

Escherichia coli Bacteroides vulgatus Phocaeicola Mediterraneibacter Oscillospiraceae Mortierella Alistipes

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium

Only in Schizophrenia

Roseburia Coprococcus Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae Lachnospiraceae

Only in Polycystic Ovary Syndrome

Lactobacillus Alistipes Akkermansia muciniphila

Host response elevated

2 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)Ceruloplasmin

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperHepcidin Lipocalin-2 ZonulinAlpha 1 Antitrypsin

Only in Polycystic Ovary Syndrome

Hs CRPInflammatory CytokinesOxidative Stress Markers TOS MDA

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Only in Polycystic Ovary Syndrome

Total Antioxidant Capacity TACSuperoxide Dismutase SODMagnesium Superoxide DismutaseTotal Antioxidant Status

Ecological state

1 shared

Shared

SCFA Depletion

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Only in Polycystic Ovary Syndrome

DysbiosisReduced Microbial DiversityEstrogen RecirculationLow Dietary FiberFermentative DysbiosisAndrogen Mediated DysbiosisObesity Amplified DysbiosisHyperandrogenism Driven DysbiosisInsulin Resistance Dysbiosis LoopMetalloestrogen BurdenAntioxidant CollapseEstrobolome DysregulationMycobiome Disruption

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase

Only in Polycystic Ovary Syndrome

Siderophores Iron AcquisitionLipopolysaccharide ProductionCopper Dependent OxidasesUrease