Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

Long COVIDandChronic Kidney Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

18: Long COVID references
34: Chronic Kidney Disease references
0: shared references

Metals elevated or accumulated

2 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Long COVID

Iron Selenium Copper Nickel

Only in Chronic Kidney Disease

Alpha-Klotho Zinc

Taxa enriched

2 shared

Shared

Enterobacteriaceae Escherichia coli

Only in Long COVID

Streptococcus Enterococcus Veillonella Candida albicans Fusobacterium nucleatum Aspergillus Klebsiella pneumoniae

Only in Chronic Kidney Disease

Eggerthella lenta Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Roseburia Bifidobacterium Akkermansia muciniphila Lachnospiraceae

Only in Long COVID

Lactobacillus

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Host response elevated

3 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)Hepcidin

Only in Long COVID

IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesCalprotectin (S100A8/A9)Zinc In Secretions

Only in Chronic Kidney Disease

CRPIL 18TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidFerritin Lipocalin-2

Host response depleted

2 shared

Shared

Glutathione (GSH)Butyrate

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgASeleniumIron In Tissues

Only in Chronic Kidney Disease

Alpha-KlothoPropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

1 shared

Shared

SCFA Depletion

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Virulence and functional enzymes

2 shared

Shared

Siderophores Beta-Glucuronidase

Only in Long COVID

LPS Synthesis TransportAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Polysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases

Only in Chronic Kidney Disease

UreaseTryptophanaseTyrosine DecarboxylaseTMA LyaseAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase