Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Schizophrenia

Copper Iron Lead Cadmium Arsenic

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Zinc

Only in Gastroesophageal Reflux Disease (GERD)

Iron Magnesium Calcium

Only in Schizophrenia

None indexed

Taxa enriched

4 shared

Taxa depleted

4 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Blautia Lachnospiraceae

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Schizophrenia

Roseburia Coprococcus Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

4 shared

Shared

IL 6IL-8 (Interleukin-8 / CXCL8)TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)

Only in Gastroesophageal Reflux Disease (GERD)

NF KappaBTLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Schizophrenia

CRPSCD14IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin Hepcidin Lipocalin-2 ZonulinAlpha 1 Antitrypsin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic Cells

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Schizophrenia

SCFA DepletionGut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisBeta-Glucuronidase

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase