Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

FibromyalgiaandChronic Kidney Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Fibromyalgia references
34: Chronic Kidney Disease references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Fibromyalgia

Copper

Only in Chronic Kidney Disease

Cadmium Lead Arsenic Mercury Chromium NickelIron In Tubular CellsThallium

Metals depleted or redistributed

1 shared

Taxa enriched

3 shared

Shared

Flavonifractor Collinsella Eggerthella lenta

Only in Fibromyalgia

Eggerthella Coprococcus StreptococcusCoprococcus 2

Only in Chronic Kidney Disease

Escherichia coli Enterobacteriaceae DesulfovibrionalesClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae Roseburia

Only in Fibromyalgia

Bacteroides vulgatus Bacteroides uniformis

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Akkermansia muciniphila Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Host response elevated

2 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum Butyrate

Only in Chronic Kidney Disease

CRPIL 18TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidHepcidin Ferritin Lipocalin-2

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

2 shared

Shared

SCFA DepletionGut Barrier Dysfunction

Only in Fibromyalgia

Butyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral Sensitization

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Virulence and functional enzymes

1 shared

Shared

Tryptophanase

Only in Fibromyalgia

Pro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseLPS BiosynthesisNeurotoxic Metabolite Production

Only in Chronic Kidney Disease

UreaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesBeta-GlucuronidaseHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase