Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 17%
- weighted overlap
- 19
- shared signals
Comparison
DepressionandChronic Kidney Disease
1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 34
- Chronic Kidney Disease references
- 1
- shared references
Metals depleted or redistributed
1 sharedShared
Only in Depression
Only in Chronic Kidney Disease
Taxa enriched
4 sharedShared
Only in Depression
Only in Chronic Kidney Disease
Eggerthella lentaDesulfovibrionalesCollinsellaClostridiaceaeMethanobacteriaParabacteroidesRuminococcusLactobacillusPseudomonas aeruginosa
Taxa depleted
5 sharedShared
Only in Depression
Only in Chronic Kidney Disease
Host response elevated
2 sharedShared
Only in Depression
Only in Chronic Kidney Disease
CRPIL 6IL 18TNF-alpha (Tumor Necrosis Factor Alpha)TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidLipocalin-2
Host response depleted
1 sharedShared
Only in Depression
Only in Chronic Kidney Disease
Alpha-KlothoButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4
Ecological state
1 sharedShared
SCFA Depletion
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Chronic Kidney Disease
Saccharolytic To Proteolytic ShiftGut Barrier DysfunctionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility
Virulence and functional enzymes
2 sharedShared
TryptophanaseBeta-Glucuronidase
Only in Depression
LPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli
Only in Chronic Kidney Disease
UreaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase