Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
14: shared signals

First condition

Second condition

Comparison

Chronic Kidney DiseaseandFibromyalgia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

34: Chronic Kidney Disease references
9: Fibromyalgia references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Chronic Kidney Disease

Cadmium Lead Arsenic Mercury Chromium NickelIron In Tubular CellsThallium

Only in Fibromyalgia

Copper

Metals depleted or redistributed

1 shared

Taxa enriched

3 shared

Shared

Eggerthella lenta Flavonifractor Collinsella

Only in Chronic Kidney Disease

Escherichia coli Enterobacteriaceae DesulfovibrionalesClostridiaceaeMethanobacteriaParabacteroides Clostridium Ruminococcus Lactobacillus Pseudomonas aeruginosa

Only in Fibromyalgia

Eggerthella Coprococcus StreptococcusCoprococcus 2

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Bifidobacterium Lachnospiraceae

Only in Chronic Kidney Disease

Lachnospira Coprococcus Prevotella Akkermansia muciniphila Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Only in Fibromyalgia

Bacteroides vulgatus Bacteroides uniformis

Host response elevated

2 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Chronic Kidney Disease

CRPIL 18TLR2 TLR4NF KappaBNLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)MalondialdehydeUric AcidHepcidin Ferritin Lipocalin-2

Only in Fibromyalgia

CeruloplasminPro Inflammatory CytokinesCopperSerum Butyrate

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Only in Fibromyalgia

GPX3Ferritin Iron SeleniumGlutathione Peroxidase 3Serotonin

Ecological state

2 shared

Shared

SCFA DepletionGut Barrier Dysfunction

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisGut Barrier DisruptionDialysis Irreversibility

Only in Fibromyalgia

Butyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral Sensitization

Virulence and functional enzymes

1 shared

Shared

Tryptophanase

Only in Chronic Kidney Disease

UreaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesBeta-GlucuronidaseHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase

Only in Fibromyalgia

Pro Inflammatory Metabolite SynthesisCopper Dependent OxidasesIndoleamine 2 3 DioxygenaseLPS BiosynthesisNeurotoxic Metabolite Production