Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

23%: weighted overlap
22: shared signals

First condition

Second condition

Comparison

SchizophreniaandType 2 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

46: Schizophrenia references
30: Type 2 Diabetes references
0: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

2 shared

Shared

Zinc Glutathione (GSH)

Only in Schizophrenia

None indexed

Only in Type 2 Diabetes

Chromium Magnesium Manganese

Taxa enriched

4 shared

Shared

Prevotella Enterobacteriaceae Streptococcus Candida albicans

Only in Schizophrenia

Lactobacillus VeillonellaSuccinivibrioTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Only in Type 2 Diabetes

Escherichia coli Enterococcus Helicobacter pylori Campylobacter jejuni

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Roseburia Blautia Bifidobacterium Lachnospiraceae

Only in Schizophrenia

Coprococcus Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Only in Type 2 Diabetes

Akkermansia muciniphila Ruminococcus Bacteroides fragilis

Host response elevated

4 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)Ceruloplasmin Hepcidin

Only in Schizophrenia

CRPSCD14IL-1beta (Interleukin-1 Beta)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperLipocalin-2 ZonulinAlpha 1 Antitrypsin

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesFerritin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Only in Type 2 Diabetes

ButyratePropionateAcetateBile AcidsZinc Chromium Manganese Magnesium

Ecological state

2 shared

Shared

SCFA DepletionGut Barrier Disruption

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Only in Type 2 Diabetes

DysbiosisLPS ElevationBile Acid DysmetabolismImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityEndotoxemiaBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsBeta-GlucuronidaseIndoleamine 2 3 DioxygenaseTryptophanase

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesSiderophoresLPS Biosynthesis EnzymesNickel-UreaseTMA Lyase CutC CutD