Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

SchizophreniaandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

46: Schizophrenia references
18: Long COVID references
0: shared references

Metals elevated or accumulated

1 shared

Metals depleted or redistributed

1 shared

Shared

Glutathione (GSH)

Only in Schizophrenia

Zinc

Only in Long COVID

Iron Selenium Copper Nickel

Taxa enriched

4 shared

Shared

Enterobacteriaceae Streptococcus Veillonella Candida albicans

Only in Schizophrenia

Lactobacillus PrevotellaSuccinivibrioTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Only in Long COVID

Enterococcus Fusobacterium nucleatum Aspergillus Escherichia coli Klebsiella pneumoniae

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Roseburia Bifidobacterium Lachnospiraceae

Only in Schizophrenia

Coprococcus Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Only in Long COVID

Lactobacillus Akkermansia muciniphila

Host response elevated

4 shared

Shared

IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)Hepcidin

Only in Schizophrenia

CRPSCD14IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperCeruloplasmin Lipocalin-2 ZonulinAlpha 1 Antitrypsin

Only in Long COVID

IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesCalprotectin (S100A8/A9)Zinc In Secretions

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAButyrate SeleniumIron In Tissues

Ecological state

2 shared

Shared

SCFA DepletionMulti Kingdom Dysbiosis

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBarrier DysfunctionBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsLPS BiosynthesisSiderophore SystemsIndoleamine 2 3 DioxygenaseTryptophanase

Only in Long COVID

LPS Synthesis TransportSiderophoresAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Polysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases