Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
11: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andPostpartum Depression

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
56: Postpartum Depression references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 MetalsNickel

Only in Postpartum Depression

Copper Cadmium Lead

Metals depleted or redistributed

3 shared

Taxa enriched

2 shared

Shared

Enterobacteriaceae Escherichia coli

Only in Gastroesophageal Reflux Disease (GERD)

Prevotella Pseudomonas Veillonella Leptotrichia Fusobacterium Bacteroides Candida albicans Fusobacterium nucleatum Mollicutes Collinsella Eggerthella

Only in Postpartum Depression

AlphaproteobacteriaBilophila Desulfovibrio Dialister Enterococcus

Taxa depleted

3 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Postpartum Depression

Phascolarctobacterium Veillonella Coprococcus Eubacterium Clostridium Butyricicoccus Holdemanella

Host response elevated

2 shared

Shared

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Gastroesophageal Reflux Disease (GERD)

IL-8 (Interleukin-8 / CXCL8)NF KappaBIL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T CellsHistamineMast Cell Mediators

Only in Postpartum Depression

HepcidinCRPIDOCeruloplasmin Copper

Host response depleted

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Only in Postpartum Depression

Zinc Tryptophan GABA (Gamma-Aminobutyric Acid)SCFAFerritin Selenium

Ecological state

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationSIBOTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Postpartum Depression

Postpartum Hormonal CrashEstrogen Progesterone WithdrawalSCFA DepletionIDO Kynurenine ActivationTryptophan DiversionHPA Axis DysregulationGut Brain Axis DisruptionBile Acid DysmetabolismPrenatal Microbiome SeedingIntergenerational Dysbiosis TransmissionBarrier DysfunctionHormonal DysregulationTryptophan Kynurenine ShuntingIntergenerational Microbiome Transmission

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal Lipases

Only in Postpartum Depression

LPS EndotoxinIDO Indoleamine 2 3 DioxygenaseBile Salt Hydrolase (BSH)Sulfite ReductaseSiderophores EnterobactinSiderophoresLPS Biosynthesis Enzymes