Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
23: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandChronic Kidney Disease

2 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
34: Chronic Kidney Disease references
2: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Mercury Cadmium Nickel Arsenic

Only in Autism Spectrum Disorder

Copper

Only in Chronic Kidney Disease

ChromiumIron In Tubular CellsThallium

Metals depleted or redistributed

2 shared

Taxa enriched

2 shared

Shared

Parabacteroides Clostridium

Only in Autism Spectrum Disorder

BacteroidesEubacterium CoprostanoligenesDesulfovibrio

Only in Chronic Kidney Disease

Escherichia coli Eggerthella lenta Enterobacteriaceae Desulfovibrionales Flavonifractor CollinsellaClostridiaceaeMethanobacteriaRuminococcus Lactobacillus Pseudomonas aeruginosa

Taxa depleted

4 shared

Shared

Coprococcus Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

Lactobacillus

Only in Chronic Kidney Disease

Roseburia Lachnospira Prevotella Akkermansia muciniphila Eubacterium rectale Ruminococcus bromii Anaerostipes Blautia

Host response elevated

6 shared

Shared

Hepcidin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 6NF KappaBMalondialdehyde

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin TransferrinIL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)Folate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Chronic Kidney Disease

CRPIL 18TLR2 TLR4NLRP3 InflammasomeSCD14Free Light Chains KappaFree Light Chains LambdaIndoxyl SulfateP Cresyl SulfateTrimethylamine N-Oxide (TMAO)Uric AcidFerritin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Chronic Kidney Disease

Alpha-Klotho ButyratePropionateAcetateIndole Propionic AcidTaurineBCAAsVitamin DTotal Antioxidant CapacityENOSGPX4

Ecological state

2 shared

Shared

Gut Barrier DysfunctionGut Barrier Disruption

Only in Autism Spectrum Disorder

Propionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Chronic Kidney Disease

Saccharolytic To Proteolytic ShiftSCFA DepletionUremic Toxin AccumulationAmmonia PH DisruptionMetal Microbiome Co ResistanceAntibiotic Resistance Gene EnrichmentVicious Cycle BidirectionalConstipation As Progression MarkerVicious Cycle Metal AccumulationStage 3b Ecological TransitionUremic Toxin ProductionMetal Antibiotic Co ResistanceFerroptosisDialysis Irreversibility

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Chronic Kidney Disease

UreaseTryptophanaseTyrosine DecarboxylaseTMA LyaseSiderophoresAromatic Amino Acid Degradation EnzymesHydrogen Sulfide SynthaseCadA Cadmium ATPaseArsC Arsenate ReductaseP Cresyl Sulfate SynthaseIndoxyl Sulfate Synthase