Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

17%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

DepressionandSchizophrenia

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Depression references
46: Schizophrenia references
0: shared references

Metals elevated or accumulated

3 shared

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Depression

Magnesium Iron Selenium

Only in Schizophrenia

Glutathione (GSH)

Taxa enriched

2 shared

Shared

Candida albicans Enterobacteriaceae

Only in Depression

Clostridium Bacteroides fragilis Escherichia coli Eggerthella Flavonifractor

Only in Schizophrenia

Lactobacillus Prevotella Streptococcus VeillonellaSuccinivibrioTrichosporonPurpureocillium Clostridia Betaproteobacteria Prevotellaceae

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lachnospiraceae Coprococcus

Only in Depression

Prevotella Dialister Lactobacillus

Only in Schizophrenia

Roseburia Blautia Saccharomyces cerevisiae Desulfovibrio Veillonellaceae

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Depression

Calprotectin (S100A8/A9)Pro Inflammatory CytokinesFerritin

Only in Schizophrenia

CRPSCD14IL 6IL-1beta (Interleukin-1 Beta)TNF-alpha (Tumor Necrosis Factor Alpha)IL-8 (Interleukin-8 / CXCL8)IL 12TGF-beta (Transforming Growth Factor Beta)NLRP3 InflammasomeComplement C4AMalondialdehydeCeruloplasmin Bound CopperLipocalin-2 ZonulinAlpha 1 Antitrypsin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Depression

Zinc Magnesium Iron SeleniumGlutathione Peroxidase

Only in Schizophrenia

Total Antioxidant CapacityVitamin DAnti Inflammatory CytokinesSCFAsZinc Finger Proteins

Ecological state

1 shared

Shared

SCFA Depletion

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Only in Schizophrenia

Gut Barrier DysfunctionTryptophan Kynurenine ShuntingTranskingdom Network DisruptionOral Gut Axis H2S EnrichmentMulti Kingdom DysbiosisMetabolic Syndrome ComorbidityGut Barrier DisruptionMicroglial ActivationTh17 Treg ImbalanceVirome Dysbiosis

Virulence and functional enzymes

3 shared

Shared

TryptophanaseBeta-GlucuronidaseLPS Biosynthesis

Only in Depression

Pro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli

Only in Schizophrenia

Tryptophan Catabolism EnzymesH2S Producing Enzyme SystemsSiderophore SystemsIndoleamine 2 3 Dioxygenase